Rau Tilman, Soeder Stephan, Olk Alexander, Aigner Thomas
Department of Pathology, Friedrich-Alexander University of Erlangen-Nuremberg, D-91054 Erlangen, Germany.
Ann Diagn Pathol. 2006 Oct;10(5):279-82. doi: 10.1016/j.anndiagpath.2006.03.009.
Lipomas are very common benign soft tissue neoplasms. They are usually slow-growing and may occur anywhere in the body. Mature cartilage and bone arising in a lipoma is a rare event and is mostly associated with a parosteal localization of the neoplasm. We describe a new case of osteochondrolipoma showing not only major adipocytic differentiation but also areas of fibrocytic and cartilaginous cell differentiation and bone formation (both endochondral and membranous). The occurrence of at least 4 distinct directions of mesenchymal cell differentiation within a benign neoplasia underlines the concept of multilineage differentiation of pluripotent mesenchymal stem cells. Such a multidirectional potential was recently well established in vitro in stem cells present in adult adipocytic tissue.
脂肪瘤是非常常见的良性软组织肿瘤。它们通常生长缓慢，可发生于身体的任何部位。脂肪瘤中出现成熟的软骨和骨是一种罕见情况，且大多与肿瘤的骨膜下定位有关。我们描述了一例新的骨软骨脂肪瘤病例，该病例不仅显示出主要的脂肪细胞分化，还存在纤维细胞和软骨细胞分化以及骨形成（软骨内成骨和膜内成骨）区域。在一个良性肿瘤内出现至少4种不同的间充质细胞分化方向，突出了多能间充质干细胞多谱系分化的概念。最近在成人脂肪组织中的干细胞体外实验中很好地证实了这种多向潜能。
