van Hooff J P, Gelens M, Boots J M, van Duijnhoven E M, Dackus J, Christiaans M H
University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands.
Transplant Proc. 2006 Sep;38(7):1987-91. doi: 10.1016/j.transproceed.2006.06.049.
An update is given about some factors leading to loss of renal allograft, especially in relation to the use of tacrolimus and cyclosporine. We discuss both immunological, such as suboptimal immunosuppression, acute rejection, and noncompliance, as well as nonimmunological factor's such as hypertension, hyperlipidemia, chronic toxic effects of immunosuppressants, older donors, and delayed graft function.
本文介绍了导致肾移植失败的一些因素的最新情况，特别是与他克莫司和环孢素的使用相关的因素。我们讨论了免疫因素，如免疫抑制不足、急性排斥反应和不依从性，以及非免疫因素，如高血压、高脂血症、免疫抑制剂的慢性毒性作用、老年供体和移植肾功能延迟。
