Miharada Kenichi, Hiroyama Takashi, Sudo Kazuhiro, Nagasawa Toshiro, Nakamura Yukio
Cell Engineering Division, RIKEN BioResource Center, Koyadai 3-1-1, Tsukuba, Ibaraki 305-0074, Japan.
Nat Biotechnol. 2006 Oct;24(10):1255-6. doi: 10.1038/nbt1245. Epub 2006 Sep 17.
Erythroblast enucleation is thought to be largely dependent on signals mediated by other cells, such as macrophages. In an attempt to improve the in vitro production of red blood cells (RBCs) from immature hematopoietic progenitor cells, we have developed a method to produce enucleated RBCs efficiently in the absence of feeder cells. Our method may represent an efficient way to produce transfusable RBCs on a large scale from hematopoietic progenitors.
成红细胞去核被认为在很大程度上依赖于其他细胞（如巨噬细胞）介导的信号。为了提高从未成熟造血祖细胞体外生产红细胞（RBC）的效率，我们开发了一种在无饲养细胞的情况下高效生产去核RBC的方法。我们的方法可能代表了一种从造血祖细胞大规模生产可用于输血的RBC的有效途径。
