在手性反应介质中，达尼谢夫斯基双烯与亚胺的不对称氮杂狄尔斯-阿尔德反应。
Asymmetric aza-Diels-Alder reaction of Danishefsky's diene with imines in a chiral reaction medium.
作者信息
Pégot Bruce, Nguyen Van Buu Olivier, Gori Didier, Vo-Thanh Giang
机构信息
Laboratoire de Chimie des Procédés et Substances Naturelles, ICMMO, CNRS UMR 8182, Université Paris-Sud, 91405 Orsay Cedex, France.
出版信息
Beilstein J Org Chem. 2006 Sep 18;2:18. doi: 10.1186/1860-5397-2-18.
The asymmetric aza-Diels-Alder reaction of chiral imines with Danishefsky's diene in chiral ionic liquids provides the corresponding cycloadduct with moderate to high diastereoselectivity. The reaction has proved to perform better at room temperature in ionic liquids without either Lewis acid catalyst or organic solvent. Chiral ionic liquids are recycled while their efficiency is preserved.
手性亚胺与达尼谢夫斯基双烯在手性离子液体中的不对称氮杂狄尔斯-阿尔德反应可提供具有中等至高非对映选择性的相应环加成产物。事实证明，该反应在离子液体中于室温下进行时，无需路易斯酸催化剂或有机溶剂，效果更佳。手性离子液体可循环利用，同时保持其效率。
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