Hauber Hans-Peter, Foley Susan C, Hamid Qutayba
McGill University, Montreal, Quebec.
Can Respir J. 2006 Sep;13(6):327-35. doi: 10.1155/2006/901417.
Mucus overproduction and hypersecretion are commonly observed in chronic inflammatory lung disease. Mucins are gel-forming glycoproteins that can be stimulated by a variety of mediators. The present review addresses the mechanisms involved in the upregulation of secreted mucins. Mucin induction by neutrophil elastase, bacteria, cytokines, growth factors, smoke and cystic fibrosis transmembrane conductance regulator malfunction are also discussed.
在慢性炎症性肺病中，通常会观察到黏液过度产生和分泌过多的现象。黏蛋白是可形成凝胶的糖蛋白，可被多种介质刺激。本综述探讨了分泌型黏蛋白上调所涉及的机制。还讨论了中性粒细胞弹性蛋白酶、细菌、细胞因子、生长因子、烟雾和囊性纤维化跨膜传导调节因子功能障碍对黏蛋白的诱导作用。
