Kerner Pierre, Zelada González Fabiola, Le Gouar Martine, Ledent Valérie, Arendt Detlev, Vervoort Michel
Laboratoire Evolution et Développement des protostomiens, Centre de Génétique Moléculaire-CNRS UPR 2167, 1 avenue de la terrasse, 91198 Gif-sur-Yvette cedex, France.
Dev Genes Evol. 2006 Dec;216(12):821-8. doi: 10.1007/s00427-006-0100-9. Epub 2006 Sep 16.
Orthologs of the Drosophila gap gene hunchback have been isolated so far only in protostomes. Phylogenetic analysis of recently available genomic data allowed us to confirm that hunchback genes are widely found in protostomes (both lophotrochozoans and ecdysozoans). In contrast, no unequivocal hunchback gene can be found in the genomes of deuterostomes and non-bilaterians. We cloned hunchback in the marine polychaete annelid Platynereis dumerilii and analysed its expression during development. In this species, hunchback displays an expression pattern indicative of a role in mesoderm formation and neurogenesis, and similar to the expression found for hunchback genes in arthropods. These data suggest altogether that these functions are ancestral to protostomes.
迄今为止，果蝇间隙基因驼背蛋白的直系同源基因仅在原口动物中被分离出来。对最近可得的基因组数据进行系统发育分析，使我们能够确认驼背蛋白基因在原口动物（包括冠轮动物和蜕皮动物）中广泛存在。相比之下，在后口动物和非两侧对称动物的基因组中未发现明确的驼背蛋白基因。我们在海洋多毛纲环节动物杜氏阔沙蚕中克隆了驼背蛋白，并分析了其在发育过程中的表达情况。在这个物种中，驼背蛋白呈现出一种表明其在中胚层形成和神经发生中起作用的表达模式，且与在节肢动物中发现的驼背蛋白基因的表达相似。这些数据共同表明，这些功能是原口动物所共有的。
