David-Watine B, Israël A, Kourilsky P
Unité de Biologie Moléculaire du Gène-U.277 INSERM, UAC 115 CNRS, Institut Pasteur, Paris, France.
Immunol Today. 1990 Aug;11(8):286-92. doi: 10.1016/0167-5699(90)90114-o.
The expression of mouse MHC class I genes and their products in vivo reveals complex patterns of regulation. Different promoter elements, which are required for gene activation or modulation in response to various external stimuli, have now been characterized as well as the proteins that bind to them. As described here by Brigitte David-Watine and colleagues, the picture that has gradually emerged from these in vitro studies is of an intricate interplay of transacting factors that ultimately lead to the fine tuning of MHC class I expression in vivo.
小鼠MHC I类基因及其产物在体内的表达揭示了复杂的调控模式。现已鉴定出不同的启动子元件，它们是基因响应各种外部刺激而激活或调节所必需的，同时也鉴定出了与之结合的蛋白质。正如布里吉特·大卫 - 瓦廷及其同事在此所描述的，这些体外研究逐渐呈现出一幅图景：反式作用因子之间存在错综复杂的相互作用，最终导致体内MHC I类表达的精细调控。
