Mizumatsu Shinichiro, Nishimura Takushi, Sakai Kyoji, Goto Masaki, Sugatani Hiroshi, Higashi Toru
Department of Neurosurgery, Himeji Central Hospital, 2-36, Miyake, Shikama-ku, Himeji, Hyogo 672-8501, Japan.
No Shinkei Geka. 2006 Sep;34(9):955-60.
A case with brain metastasis involving bilateral middle cerebellar peduncles (bMCP) was reported. A 71-year-old male with gastric cancer was treated for multiple brain metastasis by gamma knife radiosurgery (GKR) in September, 2004. Two months after the initial GKR, MRI showed asymmetrical enhanced lesions involving bMCP. A few months later, MRI revealed an expansional infiltration of bMCP lesions. The patient had presented with headache loss of appetite, cerebellar ataxia, diplopia and slight dysmetria. PET showed 2-deoxy-2- [18F] fluoro-D-glucose (FDG) uptake of the bMCP lesions. The lesions were diagnosed as brain metastasis of gastric cancer. The patient underwent his second GKR (marginal dose : 19Gy, maximum dose 38Gy) MRI revealed the disappearance of the tumors 3 months after the second GKR. One year later, the patient showed no evidence of recurrence. For the last time, our case was diagnosed as brain metastasis from gastric cancer without meningeal carcinomatosis. It was suggested that FDG-PET can provide additional information about the lesion of bMCP. GKR may be useful to treat the tumor in bMCP.
报道了一例累及双侧小脑桥臂(bMCP)的脑转移病例。一名71岁的男性胃癌患者于2004年9月接受了伽玛刀放射外科手术(GKR)治疗多发性脑转移。初次GKR术后两个月,MRI显示累及bMCP的不对称强化病灶。几个月后,MRI显示bMCP病灶呈膨胀性浸润。患者出现头痛、食欲不振、小脑共济失调、复视和轻度辨距不良。PET显示bMCP病灶摄取2-脱氧-2- [18F]氟-D-葡萄糖(FDG)。这些病灶被诊断为胃癌脑转移。患者接受了第二次GKR(边缘剂量:19Gy,最大剂量38Gy),MRI显示第二次GKR术后3个月肿瘤消失。一年后,患者无复发迹象。最后,我们的病例被诊断为无脑膜癌病的胃癌脑转移。提示FDG-PET可提供有关bMCP病灶的额外信息。GKR可能对治疗bMCP中的肿瘤有用。