Yang Ge-Liang, Luo Tian-Hang, Zhang Hui-Qing, Ling Chang-Quan, Li Bai
Department of Integrative Oncology, Changhai Hospital, Second Military Medical University, Shanghai 200433, P.R. China.
Department of General Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, P.R. China.
Oncol Lett. 2016 Apr;11(4):2893-2895. doi: 10.3892/ol.2016.4288. Epub 2016 Mar 1.
Gastric cancer with brain metastasis is rare. The present study reports a case of gastric cancer with isolated brain metastasis 1 year after gastrectomy. To the best of our knowledge, there have been no prior reports of solitary brain metastasis from gastric cancer with peripheral nervous system symptoms. A distal gastrectomy was performed on a 60-year-old male patient with gastric cancer in November 2012. Postoperative pathological analysis revealed a moderately differentiated adenocarcinoma with tumor invasion into the serosa and metastasis to one dissected lymph node. No abnormalities were found at follow-up examination. However, a tumor representing metastasis to the brain was recognized by a cranial enhanced magnetic resonance imaging examination 1 year after gastrectomy, which was performed when the patient exhibited numbness and thigmesthesia. The patient was administered 30 Gy of stereotactic radiotherapy, delivered in 5 fractions. The patient succumbed to disease 10 months subsequent to undergoing radiotherapy. This case report suggests that gastric cancer may re-present as brain metastasis with peripheral nervous system symptoms.
胃癌伴脑转移较为罕见。本研究报告了1例胃癌患者在胃切除术后1年出现孤立性脑转移的病例。据我们所知，此前尚无关于胃癌孤立性脑转移伴周围神经系统症状的报道。2012年11月，对一名60岁的男性胃癌患者实施了远端胃切除术。术后病理分析显示为中分化腺癌，肿瘤侵犯至浆膜层，并转移至1个清扫淋巴结。随访检查未发现异常。然而，在胃切除术后1年，当患者出现麻木和触觉异常时，头颅增强磁共振成像检查发现了脑转移瘤。患者接受了30 Gy的立体定向放射治疗，分5次进行。放疗后10个月，患者死于该疾病。本病例报告提示，胃癌可能以伴有周围神经系统症状的脑转移形式再次出现。
