Burlev V A, Pavlovich S V, Il'yasova N A
Research Center of Obstetrics, Gynecology, and Perinatology, Russian Academy of Medical Sciences, Moscow.
Bull Exp Biol Med. 2006 Feb;141(2):204-7. doi: 10.1007/s10517-006-0128-x.
Apoptosis and proliferative activity of the glandular epithelium and endometrial stroma in patients with peritoneal endometriosis and in women of reproductive age without endometriosis were studied at various stages of menstrual cycle. Differences in the intensity of apoptosis were revealed manifesting in changed expression of proteins in the glandular epithelium of patients with endometriosis during the secretory phase of the menstrual cycle compared to normal. Proliferative activity of the glandular epithelium in the proliferative phase was higher than in the secretory phase. Our results suggest that the imbalance between apoptosis proteins in the endometrium plays a role in the pathogenesis of peritoneal endometriosis.
在月经周期的不同阶段，对患有腹膜子宫内膜异位症的患者以及无子宫内膜异位症的育龄妇女的腺上皮和子宫内膜基质的凋亡及增殖活性进行了研究。研究发现，与正常情况相比，在月经周期的分泌期，子宫内膜异位症患者腺上皮中蛋白质表达发生变化，这表明凋亡强度存在差异。增殖期腺上皮的增殖活性高于分泌期。我们的结果表明，子宫内膜中凋亡蛋白之间的失衡在腹膜子宫内膜异位症的发病机制中起作用。
