Andes David
Department of Medicine, Infectious Diseases Section, University of Wisconsin, Madison, WI 53792, USA.
Infect Dis Clin North Am. 2006 Sep;20(3):679-97. doi: 10.1016/j.idc.2006.06.007.
Application of pharmacodynamic principles to antifungal drug therapy of Candida and Aspergillus infections has provided and understanding of the relationship between drug dosing and treatment efficacy. Observations of the pharmacodynamics of triazoles and AmB have correlated with the results of clinical trials and have proven useful for validation of in vitro susceptibility breakpoints. Although there remain many unanswered questions regarding antifungal pharmacodynamics, available data suggest usefulness in the application of pharmacodynamics to antifungal clinical development. Future application of these principles should aid in the design of optimal combination antifungal therapies.
将药效学原理应用于念珠菌和曲霉菌感染的抗真菌药物治疗，有助于理解给药剂量与治疗效果之间的关系。对三唑类药物和两性霉素B药效学的观察结果与临床试验结果相关，并已证明有助于验证体外药敏试验的折点。尽管关于抗真菌药效学仍有许多未解决的问题，但现有数据表明将药效学应用于抗真菌临床开发是有用的。这些原理的未来应用应有助于设计最佳的联合抗真菌治疗方案。
