Wiegelmann W, Borchard F, Irmscher K
Arzneimittelforschung. 1975 Jun;25(6):849-51.
A female patient developed a recurrent hepatitis-like liver damage after ingestion of a laxative containing 4,4'-(2-quinolyl-methylene)-diphenol-hydrochloride. After cessation of the drug the clinical picture improved. The hyperbilirubinemia decreased and the definitely elevated GOT, GPT, alkaline phosphatase and gamma-GTP became normal. Histologically hepato-cellular damage was seen with intra-hepatic cholestasis. As a cause for these symptoms, resembling those after taking oxyphenisatin-containing preparations, immunological procedures were thought responsible, such as "unpredictable hepatic drug reactions".
一名女性患者在摄入含有4,4'-(2-喹啉基亚甲基)-二苯酚盐酸盐的泻药后出现复发性肝炎样肝损伤。停药后临床症状改善。高胆红素血症减轻，明显升高的谷草转氨酶、谷丙转氨酶、碱性磷酸酶和γ-谷氨酰转肽酶恢复正常。组织学检查可见肝细胞损伤伴肝内胆汁淤积。由于这些症状与服用含羟苯丁酯制剂后的症状相似，推测免疫程序如“不可预测的肝脏药物反应”是其病因。
