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1
The picture of the prostatic lymphokine network is becoming increasingly complex.前列腺淋巴因子网络的情况正变得越来越复杂。
Rev Urol. 2002 Fall;4(4):171-7.
2
Differential expression of interleukin-15, a pro-inflammatory cytokine and T-cell growth factor, and its receptor in human prostate.促炎细胞因子及T细胞生长因子白细胞介素-15及其受体在人前列腺中的差异表达。
Prostate. 2001 Dec 1;49(4):251-62. doi: 10.1002/pros.10020.
3
Immunohistochemical expression of interleukin-2 receptor and interleukin-6 in patients with prostate cancer and benign prostatic hyperplasia: association with asymptomatic inflammatory prostatitis NIH category IV.白细胞介素-2受体和白细胞介素-6在前列腺癌和良性前列腺增生患者中的免疫组化表达：与无症状性炎症性前列腺炎NIH IV类的关联
Scand J Urol. 2015 Apr;49(2):120-6. doi: 10.3109/21681805.2014.971427. Epub 2014 Nov 3.
4
Biologic therapy for inflammatory bowel disease.炎症性肠病的生物治疗
Drugs. 2005;65(16):2253-86. doi: 10.2165/00003495-200565160-00002.
5
The controversial relationship between benign prostatic hyperplasia and prostate cancer: the role of inflammation.良性前列腺增生症与前列腺癌之间的争议性关系：炎症的作用。
Eur Urol. 2011 Jul;60(1):106-17. doi: 10.1016/j.eururo.2011.03.055. Epub 2011 Apr 9.
6
Interleukin 8 and the male genital tract.白细胞介素 8 与男性生殖器官。
J Reprod Immunol. 2013 Nov;100(1):54-65. doi: 10.1016/j.jri.2013.02.004. Epub 2013 Apr 20.
7
A blood-prostate barrier restricts cell and molecular movement across the rat ventral prostate epithelium.血-前列腺屏障限制细胞和分子穿过大鼠腹侧前列腺上皮。
J Urol. 2000 May;163(5):1591-4.
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Analysis of the inflammatory network in benign prostate hyperplasia and prostate cancer.良性前列腺增生和前列腺癌中炎症网络的分析
Prostate. 2004 Feb 1;58(2):121-9. doi: 10.1002/pros.10317.
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Interleukin-18 may lead to benign prostatic hyperplasia via thrombospondin-1 production in prostatic smooth muscle cells.白细胞介素-18 可能通过前列腺平滑肌细胞中血栓素结合蛋白-1 的产生导致良性前列腺增生。
Prostate. 2014 May;74(6):590-601. doi: 10.1002/pros.22773. Epub 2014 Feb 24.
10
Expression and function of pro-inflammatory interleukin IL-17 and IL-17 receptor in normal, benign hyperplastic, and malignant prostate.促炎白细胞介素IL-17和IL-17受体在正常、良性增生和恶性前列腺组织中的表达及功能
Prostate. 2003 Aug 1;56(3):171-82. doi: 10.1002/pros.10238.

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Diagnostic efficacy of systemic immune-inflammation biomarkers in benign prostatic hyperplasia using receiver operating characteristic and artificial neural network.应用受试者工作特征和人工神经网络评估全身性免疫炎症生物标志物在良性前列腺增生中的诊断效能。
Sci Rep. 2023 Sep 8;13(1):14801. doi: 10.1038/s41598-023-41781-3.
2
Applications of Vertebrate Models in Studying Prostatitis and Inflammation-Associated Prostatic Diseases.脊椎动物模型在前列腺炎及炎症相关前列腺疾病研究中的应用
Front Mol Biosci. 2022 Jul 5;9:898871. doi: 10.3389/fmolb.2022.898871. eCollection 2022.
3
IL-27/IL-27RA signaling may modulate inflammation and progression of benign prostatic hyperplasia via suppressing the LPS/TLR4 pathway.白细胞介素-27/白细胞介素-27受体信号通路可能通过抑制脂多糖/ Toll样受体4途径来调节良性前列腺增生的炎症反应和进展。
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Tumor Microenvironment in Prostate Cancer: Toward Identification of Novel Molecular Biomarkers for Diagnosis, Prognosis, and Therapy Development.前列腺癌中的肿瘤微环境：迈向用于诊断、预后和治疗开发的新型分子生物标志物的鉴定
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5
Characterization of infiltrating lymphocytes in human benign and malignant prostate tissue.人良性和恶性前列腺组织中浸润淋巴细胞的特征分析
Oncotarget. 2017 Jul 24;8(36):60257-60269. doi: 10.18632/oncotarget.19528. eCollection 2017 Sep 1.
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Molecular pathogenesis of human prostate basal cell hyperplasia.人类前列腺基底细胞增生的分子发病机制
Prostate. 2017 May;77(13):1344-1355. doi: 10.1002/pros.23394. Epub 2017 Aug 10.
7
Peripheral Zone Inflammation Is Not Strongly Associated With Lower Urinary Tract Symptom Incidence and Progression in the Placebo Arm of the Prostate Cancer Prevention Trial .在前列腺癌预防试验的安慰剂组中，外周区炎症与下尿路症状的发生率及进展并无紧密关联。
Prostate. 2016 Nov;76(15):1399-408. doi: 10.1002/pros.23224. Epub 2016 Jun 21.
8
Interleukin-17 Induces Expression of Chemokines and Cytokines in Prostatic Epithelial Cells but Does Not Stimulate Cell Growth In Vitro.白细胞介素-17诱导前列腺上皮细胞中趋化因子和细胞因子的表达，但在体外不刺激细胞生长。
Int J Med Biol Front. 2012;18(8):629-644.
9
Infiltrating T cells promote prostate cancer metastasis via modulation of FGF11→miRNA-541→androgen receptor (AR)→MMP9 signaling.浸润性T细胞通过调节FGF11→miRNA-541→雄激素受体（AR）→MMP9信号通路促进前列腺癌转移。
Mol Oncol. 2015 Jan;9(1):44-57. doi: 10.1016/j.molonc.2014.07.013. Epub 2014 Jul 29.
10
Metabolic syndrome and prostate abnormalities in male subjects of infertile couples.不育夫妇男性受试者的代谢综合征与前列腺异常
Asian J Androl. 2014 Mar-Apr;16(2):295-304. doi: 10.4103/1008-682X.122341.

本文引用的文献

1
Increased expression of lymphocyte-derived cytokines in benign hyperplastic prostate tissue, identification of the producing cell types, and effect of differentially expressed cytokines on stromal cell proliferation.良性增生性前列腺组织中淋巴细胞衍生细胞因子表达增加、产生细胞类型的鉴定以及差异表达细胞因子对基质细胞增殖的影响。
Prostate. 2002 Jun 1;52(1):43-58. doi: 10.1002/pros.10084.
2
Differential expression of interleukin-15, a pro-inflammatory cytokine and T-cell growth factor, and its receptor in human prostate.促炎细胞因子及T细胞生长因子白细胞介素-15及其受体在人前列腺中的差异表达。
Prostate. 2001 Dec 1;49(4):251-62. doi: 10.1002/pros.10020.
3
T cell infiltration of the prostate induced by androgen withdrawal in patients with prostate cancer.前列腺癌患者雄激素撤退诱导的前列腺T细胞浸润。
Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14565-70. doi: 10.1073/pnas.251140998.
4
Interleukin-6 is an autocrine growth factor in human prostate cancer.白细胞介素-6是人类前列腺癌中的一种自分泌生长因子。
Am J Pathol. 2001 Dec;159(6):2159-65. doi: 10.1016/S0002-9440(10)63067-2.
5
Interleukin-8 is a paracrine inducer of fibroblast growth factor 2, a stromal and epithelial growth factor in benign prostatic hyperplasia.白细胞介素-8是成纤维细胞生长因子2的旁分泌诱导剂，成纤维细胞生长因子2是良性前列腺增生中的一种基质和上皮生长因子。
Am J Pathol. 2001 Jul;159(1):139-47. doi: 10.1016/S0002-9440(10)61681-1.
6
Multiple signal transduction pathways mediate interleukin-4-induced 3beta-hydroxysteroid dehydrogenase/Delta5-Delta4 isomerase in normal and tumoral target tissues.多种信号转导途径介导白细胞介素-4诱导的正常和肿瘤靶组织中的3β-羟基类固醇脱氢酶/Δ5-Δ4异构酶。
J Steroid Biochem Mol Biol. 2001 Jan-Mar;76(1-5):213-25. doi: 10.1016/s0960-0760(00)00148-5.
7
Immune response in hormonally-induced prostatic hyperplasia in the dog.犬激素诱导性前列腺增生中的免疫反应。
Vet Immunol Immunopathol. 2001 Feb 10;78(3-4):297-303. doi: 10.1016/s0165-2427(01)00236-7.
8
Morphologic transitions between proliferative inflammatory atrophy and high-grade prostatic intraepithelial neoplasia.增殖性炎性萎缩与高级别前列腺上皮内瘤变之间的形态学转变。
Urology. 2000 Nov 1;56(5):828-32. doi: 10.1016/s0090-4295(00)00776-7.
9
Expression of the VEGF-receptor Flt-1 in benign, premalignant and malignant prostate tissues.血管内皮生长因子受体Flt-1在前列腺良性、癌前及恶性组织中的表达。
J Urol. 2000 Aug;164(2):506-10.
10
Expression of proinflammatory genes during estrogen-induced inflammation of the rat prostate.雌激素诱导的大鼠前列腺炎症过程中促炎基因的表达
Prostate. 2000 Jun 15;44(1):19-25. doi: 10.1002/1097-0045(20000615)44:1<19::aid-pros3>3.0.co;2-s.

前列腺淋巴因子网络的情况正变得越来越复杂。

The picture of the prostatic lymphokine network is becoming increasingly complex.

作者信息

Steiner Georg E, Djavan Bob, Kramer Gero, Handisurya Alessandra, Newman Martin, Lee Chung, Marberger Michael

出版信息

Rev Urol. 2002 Fall;4(4):171-7.

PMID:16985676
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1475993/
Abstract

The immunology of the prostate has recently developed into a new field of research in urology. Although we do not yet understand why the leukocyte population increases, we know that most resected prostate tissue shows signs of an inflammatory reaction. Different types of inflammation exist, and must be distinguished carefully according to distribution and location of leukocytes and histology of the surrounding tissue. This article reviews recent findings and discusses the complex mechanisms involved in the prostatic inflammatory response. The roles of estrogen, interleukin (IL)-6, IL-8, IL-15, and IL-17 are examined.

摘要

前列腺免疫学最近已发展成为泌尿外科一个新的研究领域。尽管我们尚不清楚白细胞数量为何增加，但我们知道大多数切除的前列腺组织都显示出炎症反应的迹象。存在不同类型的炎症，必须根据白细胞的分布和位置以及周围组织的组织学进行仔细区分。本文综述了近期的研究发现，并讨论了前列腺炎症反应中涉及的复杂机制。研究了雌激素、白细胞介素（IL）-6、IL-8、IL-15和IL-17的作用。