• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Predicting compound selectivity by self-organizing maps: cross-activities of metabotropic glutamate receptor antagonists.

作者信息

Noeske Tobias, Sasse Britta C, Stark Holger, Parsons Christopher G, Weil Tanja, Schneider Gisbert

机构信息

Johann Wolfgang Goethe University, Institute of Organic Chemistry and Chemical Biology ZAFES/CMP, Siesmayerstr 70, Frankfurt, Germany.

出版信息

ChemMedChem. 2006 Oct;1(10):1066-8. doi: 10.1002/cmdc.200600147.

DOI:10.1002/cmdc.200600147
PMID:16986201
Abstract
摘要

相似文献

1
Predicting compound selectivity by self-organizing maps: cross-activities of metabotropic glutamate receptor antagonists.通过自组织映射预测化合物选择性:代谢型谷氨酸受体拮抗剂的交叉活性
ChemMedChem. 2006 Oct;1(10):1066-8. doi: 10.1002/cmdc.200600147.
2
Rational design of 7-arylquinolines as non-competitive metabotropic glutamate receptor subtype 5 antagonists.7-芳基喹啉作为非竞争性代谢型谷氨酸受体5拮抗剂的合理设计。
Bioorg Med Chem Lett. 2007 Aug 15;17(16):4415-8. doi: 10.1016/j.bmcl.2007.06.030. Epub 2007 Jun 10.
3
New allosteric modulators of metabotropic glutamate receptor 5 (mGluR5) found by ligand-based virtual screening.基于配体的虚拟筛选发现的代谢型谷氨酸受体5(mGluR5)新型变构调节剂。
Chembiochem. 2005 Apr;6(4):620-5. doi: 10.1002/cbic.200400332.
4
Arylmethoxypyridines as novel, potent and orally active mGlu5 receptor antagonists.芳基甲氧基吡啶作为新型、强效且口服活性的代谢型谷氨酸受体5(mGlu5)拮抗剂。
Bioorg Med Chem Lett. 2006 Apr 1;16(7):1892-7. doi: 10.1016/j.bmcl.2005.12.088. Epub 2006 Jan 24.
5
Cyclohexenyl- and dehydropiperidinyl-alkynyl pyridines as potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists.环己烯基和脱氢哌啶基炔基吡啶作为有效的代谢型谷氨酸5(mGlu5)受体拮抗剂。
Bioorg Med Chem Lett. 2005 Oct 15;15(20):4589-93. doi: 10.1016/j.bmcl.2005.06.099.
6
Structure-activity relationships in a novel series of 7-substituted-aryl quinolines and 5-substituted-aryl benzothiazoles at the metabotropic glutamate receptor subtype 5.新型 7-取代芳基喹啉和 5-取代芳基苯并噻唑类代谢型谷氨酸受体 5 亚型的构效关系。
Bioorg Med Chem. 2010 May 1;18(9):3026-35. doi: 10.1016/j.bmc.2010.03.053. Epub 2010 Mar 27.
7
3-[Substituted]-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)benzonitriles: identification of highly potent and selective metabotropic glutamate subtype 5 receptor antagonists.3-[取代基]-5-(5-吡啶-2-基-2H-四氮唑-2-基)苯甲腈:高效且选择性代谢型谷氨酸受体5亚型拮抗剂的鉴定
Bioorg Med Chem Lett. 2005 Nov 15;15(22):5061-4. doi: 10.1016/j.bmcl.2005.07.062. Epub 2005 Sep 23.
8
Dipyridyl amines: potent metabotropic glutamate subtype 5 receptor antagonists.联吡啶胺:强效代谢型谷氨酸受体5亚型拮抗剂。
Bioorg Med Chem Lett. 2005 Oct 1;15(19):4350-3. doi: 10.1016/j.bmcl.2005.06.059.
9
5-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-2,3'-bipyridine: a highly potent, orally active metabotropic glutamate subtype 5 (mGlu5) receptor antagonist with anxiolytic activity.5-[(2-甲基-1,3-噻唑-4-基)乙炔基]-2,3'-联吡啶:一种高效、口服活性的代谢型谷氨酸5(mGlu5)受体拮抗剂,具有抗焦虑活性。
Bioorg Med Chem Lett. 2004 Aug 2;14(15):3993-6. doi: 10.1016/j.bmcl.2004.05.037.
10
Non-competitive inhibitors of metabotropic glutamate receptor 5 (mGluR5).代谢型谷氨酸受体5(mGluR5)的非竞争性抑制剂
Bioorg Med Chem Lett. 2005 Jun 2;15(11):2876-80. doi: 10.1016/j.bmcl.2005.03.089.

引用本文的文献

1
Analysis of the uncharted, druglike property space by self-organizing maps.自组织映射分析未知的、类似药物的物质空间。
Mol Divers. 2022 Oct;26(5):2427-2441. doi: 10.1007/s11030-021-10343-y. Epub 2021 Oct 28.
2
Identification of Novel Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Acting at Site Distinct from 2-Methyl-6-(phenylethynyl)-pyridine Binding.鉴定代谢型谷氨酸受体亚型 5 的新型变构调节剂,其作用部位与 2-甲基-6-(苯乙炔基)吡啶结合部位不同。
ACS Chem Neurosci. 2019 Aug 21;10(8):3427-3436. doi: 10.1021/acschemneuro.8b00227. Epub 2019 Jun 17.
3
Development and Testing of Druglike Screening Libraries.
药物筛选库的开发与测试。
J Chem Inf Model. 2019 Jan 28;59(1):53-65. doi: 10.1021/acs.jcim.8b00537. Epub 2019 Jan 3.
4
Microfluidic-Based Multi-Organ Platforms for Drug Discovery.用于药物发现的基于微流控的多器官平台。
Micromachines (Basel). 2016 Sep 8;7(9):162. doi: 10.3390/mi7090162.
5
Computationally-guided drug repurposing enables the discovery of kinase targets and inhibitors as new schistosomicidal agents.计算指导的药物再利用使激酶靶标和抑制剂的发现成为新的杀血吸虫药物。
PLoS Comput Biol. 2018 Oct 22;14(10):e1006515. doi: 10.1371/journal.pcbi.1006515. eCollection 2018 Oct.
6
Realizing drug repositioning by adapting a recommendation system to handle the process.通过调整推荐系统来处理流程,实现药物再定位。
BMC Bioinformatics. 2018 Apr 12;19(1):136. doi: 10.1186/s12859-018-2142-1.
7
Synthesis, Molecular Properties Estimations, and Dual Dopamine D and D Receptor Activities of Benzothiazole-Based Ligands.基于苯并噻唑配体的合成、分子性质估算及多巴胺D和D受体双重活性
Front Chem. 2017 Sep 12;5:64. doi: 10.3389/fchem.2017.00064. eCollection 2017.
8
Prediction of new drug indications based on clinical data and network modularity.基于临床数据和网络模块性的新药适应症预测
Sci Rep. 2016 Sep 28;6:32530. doi: 10.1038/srep32530.
9
Self Organizing Map-Based Classification of Cathepsin k and S Inhibitors with Different Selectivity Profiles Using Different Structural Molecular Fingerprints: Design and Application for Discovery of Novel Hits.基于自组织映射的组织蛋白酶k和S抑制剂分类:利用不同结构分子指纹分析不同选择性概况,新型活性化合物发现的设计与应用
Molecules. 2016 Jan 30;21(2):175. doi: 10.3390/molecules21020175.
10
An integrated structure- and system-based framework to identify new targets of metabolites and known drugs.一种基于结构和系统的综合框架,用于识别代谢物和已知药物的新靶点。
Bioinformatics. 2015 Dec 15;31(24):3922-9. doi: 10.1093/bioinformatics/btv477. Epub 2015 Aug 18.