Pavlova T V, Petrukhin V A, Riabykh R V, Pavlova L A
Arkh Patol. 2006 Jul-Aug;68(4):22-4.
Impaired microcirculation with evolving sludge phenomenon and thrombosis underlie placental changes in maternal thyroid disease. Capillary blood circulatory defect is largely due to villous immaturity. Placental tissue ischemia gives rise to fibrinoid, sclerosis, and alternative processes. Dysadaptive changes are mostly observed in thyrotoxicosis and hypothyroidism. Adaptive processes evolving at the ultrastructural level are best pronounced in euthyroid goiter.
微循环障碍伴不断发展的血液淤滞现象和血栓形成是母体甲状腺疾病中胎盘变化的基础。毛细血管血液循环缺陷主要归因于绒毛不成熟。胎盘组织缺血会引发纤维蛋白样变性、硬化及其他变化过程。适应不良性变化多见于甲状腺毒症和甲状腺功能减退症。在甲状腺功能正常的甲状腺肿中，超微结构水平上的适应性变化最为明显。
