Hondermarck H, Courty J, Boilly B, Thomas D
Laboratoire de biologie des facteurs de croissance, Université des Sciences et Techniques de Lille, Villeneuve, France.
Experientia. 1990 Sep 15;46(9):973-4. doi: 10.1007/BF01939392.
Iodinated acidic or basic fibroblast growth factor (aFGF or bFGF) were separately injected into adult mice to follow their distribution in the main organs of the animals. Iodinated FGFs intravenously injected into mice cleared from blood with a T1/2 of 30 s. They mainly bound to kidney, liver and spleen. The binding of FGFs to these organs was maintained when the latter were washed with a physiological buffer containing 0.15 M NaCl, but it was eliminated when the buffer contained 2 M NaCl. Simultaneous injections of the FGFs together with increasing doses of heparin weakened the binding of FGF to vessels in a dose-dependent manner.
将碘化酸性或碱性成纤维细胞生长因子（aFGF或bFGF）分别注射到成年小鼠体内，以追踪它们在动物主要器官中的分布情况。静脉注射到小鼠体内的碘化FGF以30秒的半衰期从血液中清除。它们主要与肾脏、肝脏和脾脏结合。当用含有0.15M NaCl的生理缓冲液洗涤这些器官时，FGF与它们的结合得以维持，但当缓冲液含有2M NaCl时，这种结合就会消失。同时注射FGF与剂量不断增加的肝素会以剂量依赖的方式减弱FGF与血管的结合。
