Hegnhøj J, Hansen C P, Rannem T, Søbirk H, Andersen L B, Andersen J R
Department of Medicine P, Rigshospitalet, University of Copenhagen, Denmark.
Gut. 1990 Sep;31(9):1076-9. doi: 10.1136/gut.31.9.1076.
We investigated exocrine pancreatic function in a population of patients with Crohn's disease in order to correlate the pancreatic function with clinical and laboratory variables. A total of 143 patients affected by Crohn's disease and 115 control subjects were studied. All had a Lundh meal test. As a group patients with Crohn's disease had significantly decreased activity of both amylase (p less than 0.02) and lipase (p less than 0.001) in duodenal aspirates. In patients with Crohn's disease enzyme activities were not correlated to duration of disease or to extent or localisation of previous bowel resection. The lowest enzyme values were found in patients with the most extensive bowel involvement, and they were significantly lower (p less than 0.05) than in patients with disease confined to the terminal ileum. The differences between enzyme values in other subgroups of patients were not significant. For the patient group as a whole no correlation was found between disease activity and enzyme values, but for the most uniform group of patients, those with terminal ileitis, pancreatic function was significantly lower (p less than 0.05) in patients with moderate and severe disease compared with patients with mild disease. Thus at least two factors seem to be responsible for impaired pancreatic function in Crohn's disease: firstly disease activity and secondly localisation or extent of disease.
我们对一群克罗恩病患者的胰腺外分泌功能进行了研究，以便将胰腺功能与临床和实验室变量相关联。共研究了143例克罗恩病患者和115例对照受试者。所有人都进行了伦德餐试验。作为一个群体，克罗恩病患者十二指肠抽吸物中的淀粉酶（p<0.02）和脂肪酶（p<0.001）活性均显著降低。在克罗恩病患者中，酶活性与疾病持续时间、既往肠道切除术的范围或部位无关。酶值最低的是肠道受累最广泛的患者，且显著低于（p<0.05）病变局限于回肠末端的患者。其他患者亚组之间的酶值差异不显著。对于整个患者群体，未发现疾病活动与酶值之间存在相关性，但对于最一致的患者群体，即回肠末端炎患者，中重度疾病患者的胰腺功能显著低于（p<0.05）轻度疾病患者。因此，克罗恩病患者胰腺功能受损似乎至少有两个因素：一是疾病活动，二是疾病的部位或范围。
