在β-羟基-α-氨基酸酯的合成中，通过阳离子铱配合物经由动态动力学拆分实现对映选择性和非对映选择性氢化反应。
Enantio- and diastereoselective hydrogenation via dynamic kinetic resolution by a cationic iridium complex in the synthesis of beta-hydroxy-alpha-amino acid esters.
作者信息
Makino Kazuishi, Iwasaki Masamichi, Hamada Yasumasa
机构信息
Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.
出版信息
Org Lett. 2006 Sep 28;8(20):4573-6. doi: 10.1021/ol061796v.
PMID:16986953
Abstract
Anti-selective asymmetric hydrogenation of alpha-amino-beta-keto esters via dynamic kinetic resolution under low hydrogen pressure has been achieved by an easily-handled cationic iridium complex with tetrakis[3,5-bis(trifluoromethyl)phenyl]borate (BARF) as a counterion.
摘要
通过一种易于操作的以四[3,5-双(三氟甲基)苯基]硼酸酯（BARF）作为抗衡离子的阳离子铱配合物，在低氢气压力下通过动态动力学拆分实现了α-氨基-β-酮酯的抗选择性不对称氢化。
Zotero 插件