一种监测小鼠中枢神经系统亚临床病毒感染的新方法。
A new method for monitoring subclinical virus infections of the central nervous system in mice.
作者信息
Suckling A J, Bateman S, Webb H E
出版信息
Br J Exp Pathol. 1975 Aug;56(4):287-90.
Abstract
The course of a subclinical virus infection of the central nervous system (CNS) of mice has been followed by measuring spontaneous motor activity using Animex equipment. A significant drop in activity occurred on the 5th and 6th day after inoculation with the A774 (avirulent) strain of Semliki Forest virus (SFV) before histological changes were apparent but at the same time as maximum brain virus titre. The relationship of the fall in activity to changes in the pattern of weight gain, food and water intake was also investigated.
摘要
通过使用Animex设备测量自发运动活动，对小鼠中枢神经系统（CNS）亚临床病毒感染的病程进行了跟踪。在用Semliki森林病毒（SFV）的A774（无毒）株接种后的第5天和第6天，活动出现显著下降，此时组织学变化尚不明显，但与脑病毒滴度最高时同步。还研究了活动下降与体重增加模式、食物和水摄入量变化之间的关系。
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本文引用的文献
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The course of Semliki Forest virus infection in mice.小鼠感染Semliki森林病毒的病程。
Br J Exp Pathol. 1967 Aug;48(4):395-402.
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Behaviour in emergence and open-field tests of normal and scrapie mice.
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An investigation of a new instrument to measure motor activity of small animals.
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Infection patterns in mice of an avirulent and virulent strain of Semliki Forest virus.减毒和强毒株塞姆利基森林病毒在小鼠中的感染模式
Br J Exp Pathol. 1971 Dec;52(6):669-77.
5
The virulence of original and derived strains of Semliki forest virus for mice, guinea-pigs and rabbits.塞姆利基森林病毒原始株及衍生株对小鼠、豚鼠和兔子的毒力。
J Gen Virol. 1971 Aug;12(2):141-60. doi: 10.1099/0022-1317-12-2-141.
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Encephalopathy in mice following inapparent Semliki Forest Virus (S.F.V.) infection.隐性感染Semliki森林病毒（S.F.V.）后小鼠的脑病
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Changes in drinking and feeding habits of mice with experimental scrapie.患有实验性羊瘙痒病小鼠的饮水和进食习惯变化
J Comp Pathol. 1972 Oct;82(4):415-27. doi: 10.1016/0021-9975(72)90041-2.
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