Le Rhun E, Richard F, Pasquier F
Department of Neurology, Research and Resource Memory Centre and EA 2691, University Hospital of Lille, Lille, France.
Eur J Neurol. 2006 Oct;13(10):1124-7. doi: 10.1111/j.1468-1331.2006.01455.x.
Primary progressive aphasia (PPA) syndrome is frequently misdiagnosed--particularly in favour of Alzheimer's disease (AD). Misdiagnosis is related to the heterogeneity of language disorders at onset, variability in the rate of clinical progression and the low prevalence of PPA syndrome, compared with AD. The aim of this study was to determine whether a patient's first Mini Mental Status Examination (MMSE) might provide insight into differentiating between PPA and AD. We compared item scores for the first, complete MMSE in consecutive patients with PPA versus matched patients with AD. Word recall and constructional praxis were significantly better in patients subsequently diagnosed as suffering from PPA. Patients with AD performed significantly better in terms of word registration, object naming, repetition and verbal direction. Our findings indicate that the various MMSE item scores may be helpful in differentiating PPA and AD in the first few years of the disease.
原发性进行性失语（PPA）综合征经常被误诊——尤其是被误诊为阿尔茨海默病（AD）。误诊与起病时语言障碍的异质性、临床进展速度的变异性以及与AD相比PPA综合征的低患病率有关。本研究的目的是确定患者的首次简易精神状态检查表（MMSE）是否有助于区分PPA和AD。我们比较了连续的PPA患者与匹配的AD患者首次完整MMSE的项目得分。在随后被诊断为患有PPA的患者中，单词回忆和结构运用能力明显更好。AD患者在单词登记、物体命名、复述和语言指令方面表现明显更好。我们的研究结果表明，在疾病的最初几年，MMSE的各项项目得分可能有助于区分PPA和AD。
