Osher Jason E, Wicklund Alissa H, Rademaker Alfred, Johnson Nancy, Weintraub Sandra
Department of Psychiatry and Behavioral Sciences, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.
Am J Alzheimers Dis Other Demen. 2007;22(6):468-73. doi: 10.1177/1533317507307173.
There is little information regarding the usefulness of the Mini-Mental State Examination (MMSE) for tracking progression of non-Alzheimer's disease dementias. This study examined the utility of the MMSE in capturing disease severity in the behavioral variant frontotemporal dementia (bvFTD) and primary progressive aphasia (PPA), 2 nonamnestic clinical dementia syndromes. Retrospective data from 41 bvFTD and 30 PPA patients were analyzed. bvFTD patients' change in MMSE scores over time was significantly correlated with change over time on a measure of activities of daily living. In contrast, PPA patients' MMSE scores showed greater decline over time than scores on the activities of daily living scale. Results suggest that the MMSE score, heavily dependent on language skill, overestimates dementia severity in PPA patients. However, the score may be a more accurate measure of functional impairment in bvFTD due to the influence of their executive function and attentional deficits on MMSE performance.
关于简易精神状态检查表（MMSE）在追踪非阿尔茨海默病性痴呆进展方面的有用性，相关信息较少。本研究探讨了MMSE在捕捉行为变异型额颞叶痴呆（bvFTD）和原发性进行性失语（PPA）这两种非遗忘型临床痴呆综合征的疾病严重程度方面的效用。分析了41例bvFTD患者和30例PPA患者的回顾性数据。bvFTD患者MMSE评分随时间的变化与日常生活活动量表随时间的变化显著相关。相比之下，PPA患者的MMSE评分随时间的下降幅度大于日常生活活动量表评分。结果表明，严重依赖语言技能的MMSE评分高估了PPA患者的痴呆严重程度。然而，由于bvFTD患者的执行功能和注意力缺陷对MMSE表现的影响，该评分可能是bvFTD功能损害的更准确指标。
