一种改良的恶性疟原虫生长抑制试验（GIA），用于评估疟疾流行地区血浆的活性。
A modified Plasmodium falciparum growth inhibition assay (GIA) to assess activity of plasma from malaria endemic areas.
作者信息
Mlambo Godfree, Kumar Nirbhay
机构信息
Malaria Research Institute, Department of Microbiology and Immunology, Johns Hopkins University, Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD 21205, USA.
出版信息
Exp Parasitol. 2007 Feb;115(2):211-4. doi: 10.1016/j.exppara.2006.08.003. Epub 2006 Sep 20.
Plasma samples from patients undergoing treatment in malaria endemic countries often contain anti-malaria drugs, that may overstate effects of specific antibodies in growth inhibition assays (GIA). We describe a modified assay that uses drug resistant P. falciparum parasites (W2) that circumvents the requirement for dialyzing samples that may likely contain drugs such as chloroquine and sulfadoxine/pyrimethamine (SP).
来自疟疾流行国家正在接受治疗的患者的血浆样本通常含有抗疟疾药物，这可能会在生长抑制试验（GIA）中夸大特定抗体的作用。我们描述了一种改良试验，该试验使用耐药恶性疟原虫（W2），从而避免了对可能含有氯喹和磺胺多辛/乙胺嘧啶（SP）等药物的样本进行透析的需求。
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