源自一系列N-((4-(吗啉-4-羰基)-1-(丙基磺酰基)哌啶-4-基)甲基)苯甲酰胺的甘氨酸转运体1（GlyT1）抑制剂的合成与构效关系
Synthesis and SAR of GlyT1 inhibitors derived from a series of N-((4-(morpholine-4-carbonyl)-1-(propylsulfonyl)piperidin-4-yl)methyl)benzamides.
作者信息
Zhao Zhijian, O'Brien Julie A, Lemaire Wei, Williams David L, Jacobson Marlene A, Sur Cyrille, Pettibone Doug J, Tiller Philip R, Smith Sheri, Hartman George D, Wolkenberg Scott E, Lindsley Craig W
机构信息
Department of Medicinal Chemistry, Merck and Co., Inc., PO Box 4, West Point, PA 19486, USA.
出版信息
Bioorg Med Chem Lett. 2006 Dec 1;16(23):5968-72. doi: 10.1016/j.bmcl.2006.08.131. Epub 2006 Sep 20.
PMID:16987662
Abstract
This Letter describes the synthesis and SAR, developed through an iterative analog library approach, of potent and selective non-sarcosine-derived GlyT1 inhibitors.
摘要
本信函描述了通过迭代类似物库方法开发的强效且选择性的非肌氨酸衍生的甘氨酸转运体1（GlyT1）抑制剂的合成及构效关系。
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