固态1,4 - 二氢吡啶衍生物的电离辐射效应。

The effect of ionizing radiation of 1,4-dihydropyridine derivatives in the solid state.

作者信息

Naskrent Marek, Mielcarek Jadwiga

机构信息

Department of Medical Physics, Adam Mickiewicz University, Umultowska 85, 61-614 Poznań, Poland.

出版信息

Spectrochim Acta A Mol Biomol Spectrosc. 2007 May;67(1):251-5. doi: 10.1016/j.saa.2006.07.009. Epub 2006 Jul 8.

DOI:10.1016/j.saa.2006.07.009

PMID:16987696

Abstract

Electron paramagnetic resonance (EPR) spectroscopy was used to investigate the gamma-radiation damage in the crystalline powder form of nine calcium channel blockers from the 1,4-dihydropyridine derivatives, which are in clinical use for treatment of arteria hypertension and ischemic heart disease. EPR studies have been carried out, showing the influence of irradiation and storage parameters on the nature and concentration of the free radicals trapped. EPR spectra of isardipine and felodipine showed single EPR line. EPR spectra of nifedipine, nisoldipine, nitrendipine, nimodipine, nicardipine and nilvadipine reveal a broad anisotropic signal of hyperfine interaction. No EPR signal was observed from amlodipine.

摘要

电子顺磁共振（EPR）光谱法用于研究九种1,4 - 二氢吡啶衍生物类钙通道阻滞剂结晶粉末形式中的γ辐射损伤，这些药物在临床上用于治疗动脉高血压和缺血性心脏病。已经进行了EPR研究，显示了辐照和储存参数对捕获的自由基的性质和浓度的影响。伊拉地平和平尼地平的EPR光谱显示单条EPR线。硝苯地平、尼索地平、尼群地平、尼莫地平、尼卡地平和氨氯地平的EPR光谱显示出超精细相互作用的宽各向异性信号。从氨氯地平未观察到EPR信号。