Duru Mehmet, Seyfeli Ergun, Kuvandik Guven, Kaya Hasan, Yalcin Fatih
Department of Emergency Medicine, School of Medicine, Mustafa Kemal University, 31100 Antakya, Hatay, Turkey.
Obesity (Silver Spring). 2006 Aug;14(8):1378-82. doi: 10.1038/oby.2006.156.
The aim of this study was to investigate effect of loss weight on P wave dispersion in obese subjects.
After a 12-week weight loss program (diet and medical therapy), a total of 30 (24 women and six men) obese subjects who had lost at least 10% of their original weight were included in the present study. All subjects underwent a routine standard 12-lead surface electrocardiogram. Electrocardiograms were transferred to a personal computer by a scanner and then magnified 400 times by Adobe Photoshop software (Adobe Systems, Mountain View, CA). P wave dispersion, which is also defined as the difference between the maximum P wave duration and the minimum P wave duration, was also calculated.
After a 12-week weight loss program, BMI (p < 0.001), maximum P wave duration (p < 0.001), and P wave dispersion (p < 0.001) significantly decreased. The mean percentage of weight loss was 13% (10% to 20.3%). The decrease in the level of P wave dispersion (21 +/- 10 and 7 +/- 12 ms, p < 0.002) was more prominent in Group II (>or=12% loss of their original weight) than Group I (<12% loss of their original weight) after the weight loss program. A statistically significant correlation between decrease in the level of P wave dispersion and percentage of weight loss was found (r = 0.624, p < 0.001).
Substantial weight loss in obese subjects is associated with a decrease of P wave duration and dispersion. Therefore, these observations suggest that substantial weight loss is associated with improvement in atrial repolarization abnormalities in obese subjects.
本研究旨在探讨体重减轻对肥胖受试者P波离散度的影响。
经过为期12周的减肥计划（饮食和药物治疗）后，本研究纳入了30名（24名女性和6名男性）肥胖受试者，他们的体重至少减轻了原始体重的10%。所有受试者均接受常规标准12导联体表心电图检查。心电图通过扫描仪传输至个人电脑，然后用Adobe Photoshop软件（Adobe Systems，加利福尼亚州山景城）放大400倍。还计算了P波离散度，其定义为最大P波时限与最小P波时限之差。
经过12周的减肥计划后，体重指数（p<0.001）、最大P波时限（p<0.001）和P波离散度（p<0.001）均显著降低。体重减轻的平均百分比为13%（10%至20.3%）。减肥计划后，第二组（体重减轻≥原始体重的12%）的P波离散度降低水平（21±10和7±12毫秒，p<0.002）比第一组（体重减轻<原始体重的12%）更为显著。发现P波离散度降低水平与体重减轻百分比之间存在统计学显著相关性（r=0.624，p<0.001）。
肥胖受试者体重显著减轻与P波时限和离散度降低有关。因此，这些观察结果表明，体重显著减轻与肥胖受试者心房复极异常的改善有关。
