Elkins Jacob S, Whitmer Rachel A, Sidney Stephen, Sorel Mike, Yaffe Kristine, Johnston S Claiborne
Department of Neurology, University of California, 505 Parnassus Avenue, Box 0114, San Francisco, CA 94143, USA.
Obesity (Silver Spring). 2006 Aug;14(8):1472-8. doi: 10.1038/oby.2006.167.
Obesity is a growing problem among middle-aged individuals. We investigated whether obesity in middle-aged individuals influences the need for future nursing home care and whether the risk of nursing home admission associated with obesity is greater in whites than in blacks.
The study population (N = 8804) consisted of long-term members of the Kaiser Permanente Medical Care Plan ages 75 to 85 years in 1995 who had completed a standardized, multiphasic health checkup while in their 50s. The multiphasic health checkup examinations were performed as part of routine medical care between the years 1964 and 1973 and included standardized measurements of BMI. We used health plan records to assess incident nursing home admissions from 1995 to 2002. The risk of nursing home admission associated with standard categories of midlife BMI was estimated using Cox proportional hazard analysis.
During an average follow-up of 5.1 years, the nursing home admission rate was 6.8 per 100 person-years of observation. After adjustment for comorbidities, midlife obesity predicted incident nursing home admission approximately 25 years later [hazard ratio (HR), 1.30; 95% confidence interval (CI), 1.15 to 1.46; p < 0.001]. Overweight BMI at midlife was not associated with future nursing home admission (HR, 1.05; 95% CI, 0.97 to 1.14; p = 0.23). The risk of nursing home admission associated with midlife obesity was higher in whites (HR, 1.34; 95% CI, 1.17 to 1.54; p < 0.001) than in blacks (HR 1.15; 95% CI, 0.87 to 1.52; p = 0.32), but the difference between races was not significant (p for interaction = 0.65).
Obesity among middle-aged individuals is associated with an increased risk of nursing home admission in late life and may be an important target for reducing the future societal burden of nursing home care.
肥胖在中年人群中是一个日益严重的问题。我们调查了中年人的肥胖是否会影响未来对养老院护理的需求,以及与肥胖相关的养老院入住风险在白人中是否比黑人更高。
研究人群(N = 8804)由1995年年龄在75至85岁的凯撒医疗保健计划的长期成员组成,他们在50多岁时完成了标准化的多阶段健康检查。多阶段健康检查是在1964年至1973年期间作为常规医疗护理的一部分进行的,包括对体重指数(BMI)的标准化测量。我们使用健康计划记录来评估1995年至2002年期间养老院入住情况。使用Cox比例风险分析估计与中年BMI标准类别相关的养老院入住风险。
在平均5.1年的随访期间,养老院入住率为每100人年观察期6.8例。在调整合并症后,中年肥胖可预测约25年后的养老院入住情况[风险比(HR),1.30;95%置信区间(CI),1.15至1.46;p < 0.001]。中年超重的BMI与未来养老院入住无关(HR,1.05;95%CI,0.97至1.14;p = 0.23)。与中年肥胖相关的养老院入住风险在白人中(HR,1.34;95%CI,1.17至1.54;p < 0.001)高于黑人(HR 1.15;95%CI,0.87至1.52;p = 0.32),但种族之间的差异不显著(交互作用p = 0.65)。
中年人的肥胖与晚年养老院入住风险增加有关,可能是减轻未来社会养老院护理负担的一个重要目标。