一氧化碳在心血管功能中的作用。
Role of carbon monoxide in cardiovascular function.
作者信息
Durante William, Johnson Fruzsina K, Johnson Robert A
机构信息
Department of Medical Pharmacology and Physiology, M409 Medical Sciences Building, School of Medicine, University of Missouri-Columbia, One Hospital Drive, Columbia, MO 65212, USA.
出版信息
J Cell Mol Med. 2006 Jul-Sep;10(3):672-86. doi: 10.1111/j.1582-4934.2006.tb00427.x.
Abstract
Carbon monoxide (CO) is an endogenously derived gas formed from the breakdown of heme by the enzyme heme oxygenase. Although long considered an insignificant and potentially toxic waste product of heme catabolism, CO is now recognized as a key signaling molecule that regulates numerous cardiovascular functions. Interestingly, alterations in CO synthesis are associated with many cardiovascular disorders, including atherosclerosis, septic shock, hypertension, metabolic syndrome, and ischemia-reperfusion injury. Significantly, restoration of physiologic CO levels exerts a beneficial effect in many of these settings, suggesting a crucial role for CO in maintaining cardiovascular homeostasis. In this review, we outline the actions of CO in the cardiovascular system and highlight this gas as a potential therapeutic target in treating a multitude of cardiovascular disorders.
摘要
一氧化碳（CO）是一种内源性气体，由血红素加氧酶分解血红素产生。尽管长期以来人们一直认为它是血红素分解代谢中无足轻重且可能有毒的废物，但现在CO被认为是调节多种心血管功能的关键信号分子。有趣的是，CO合成的改变与许多心血管疾病有关，包括动脉粥样硬化、脓毒性休克、高血压、代谢综合征和缺血再灌注损伤。值得注意的是，在许多这些情况下，恢复生理水平的CO会产生有益作用，这表明CO在维持心血管稳态中起关键作用。在本综述中，我们概述了CO在心血管系统中的作用，并强调这种气体作为治疗多种心血管疾病的潜在治疗靶点。
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Local administration of carbon monoxide inhibits neointima formation in balloon injured rat carotid arteries.一氧化碳局部给药可抑制大鼠颈动脉球囊损伤后新生内膜的形成。
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