半胱天冬酶-1构建了一道新的抗感染屏障。
Caspase-1 builds a new barrier to infection.
作者信息
Saleh Maya
机构信息
Department of Medicine, McGill University, Montreal H3G 1Y6, Canada.
出版信息
Cell. 2006 Sep 22;126(6):1028-30. doi: 10.1016/j.cell.2006.09.006.
PMID:16990128
Abstract
Caspase-1 promotes both the maturation of proinflammatory cytokines and apoptosis in cells infected by certain pathogens. Work by now reveals a surprising new function for caspase-1: the stimulation of membrane biogenesis to repair damage caused by bacterial pore-forming toxins. Thus, caspase-1 may promote host cell survival as a means of resistance to pathogenic bacteria.
摘要
半胱天冬酶-1在某些病原体感染的细胞中可促进促炎细胞因子的成熟和细胞凋亡。目前的研究揭示了半胱天冬酶-1一个惊人的新功能：刺激膜生物合成以修复由细菌成孔毒素造成的损伤。因此，半胱天冬酶-1可能通过促进宿主细胞存活来抵抗病原菌。
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