Satoh Koichiro, Takano Shizuko, Onogi Takashi, Ohtsuki Koji, Kobayashi Toshio
Institute of Physical Medicine and Rehabilitation, Fukushima Medical University School of Medicine, Japan.
Fukushima J Med Sci. 2006 Jun;52(1):29-33. doi: 10.5387/fms.52.29.
There have been only a few reports of serotonin syndrome developing after mono-therapy with a selective serotonin reuptake inhibitor (SSRI). We report a case of serotonin syndrome caused by long-term therapy with fluvoxamine prior to treatment with paroxetine. An 18-year-old man with spinal cord injury (SCI) at thoracic level 2-3 presented with onset of serotonin syndrome after taking fluvoxamine (50 mg per day) for 8 weeks prior to treatment with paroxetine (10 mg per day) for 6 days. He had confusion, agitation, severe headache, tachycardia (124 beats/minute), hypertension (165/118 mmHg), high fever (39.1 degrees C), and myoclonus. All of the symptoms disappeared within 24 hours after discontinuation of administration of paroxetine. This is an interesting case of serotonin syndrome that developed after minimum doses of single therapy with an SSRI in a patient with SCI.
仅有少数关于单药使用选择性5-羟色胺再摄取抑制剂（SSRI）后发生5-羟色胺综合征的报告。我们报告1例在使用帕罗西汀治疗前长期服用氟伏沙明导致5-羟色胺综合征的病例。一名胸2-3水平脊髓损伤（SCI）的18岁男性，在服用氟伏沙明（每日50mg）8周后，开始服用帕罗西汀（每日10mg）6天，随后出现5-羟色胺综合征。他出现意识模糊、烦躁不安、严重头痛、心动过速（124次/分钟）、高血压（165/118mmHg）、高热（39.1℃）及肌阵挛。停用帕罗西汀后所有症状在24小时内消失。这是1例在SCI患者中使用最低剂量的SSRI单药治疗后发生5-羟色胺综合征的有趣病例。
