Tempel K, Spath A, Stammberger I
Institut für Pharmakologie, Toxikologie und Pharmazie, Tierärztlichen Fakultät, Universität, Munich, Fed. Rep. of Germany.
Arzneimittelforschung. 1990 Jul;40(7):787-90.
The i.p. administration of ditiocarb sodium (diethyldithiocarbamate, DDC) at doses of 500 and 1000 mg/kg body wt. decreased within 1 h and in a competitive manner the ribonucleotide reductase (RNR) activity of rat thymocytes by about 25 and 40%, respectively. Under the same conditions, scheduled DNA synthesis was inhibited by almost 30 and 75%, whereas RNA synthesis remained unchanged. 1000 mg DDC/kg body wt. resulted in a long-lasting diminution in thymus weight; the spleen revealed no significant drug effects. It is suggested that the decrease of RNR activity in thymocytes of DDC-treated rats is a major determinant in the (reversible) inhibition of DNA synthesis which, in turn, may be implicated in the radio- and chemoprotective effects of the drug.
腹腔注射剂量为500和1000毫克/千克体重的二乙氨基二硫代甲酸钠（二乙基二硫代氨基甲酸盐，DDC），在1小时内可竞争性地使大鼠胸腺细胞的核糖核苷酸还原酶（RNR）活性分别降低约25%和40%。在相同条件下，预定的DNA合成被抑制了近30%和75%，而RNA合成保持不变。1000毫克DDC/千克体重导致胸腺重量长期减轻；脾脏未显示出明显的药物作用。有人认为，DDC处理的大鼠胸腺细胞中RNR活性的降低是（可逆的）DNA合成抑制的主要决定因素，而这反过来可能与该药物的放射和化学保护作用有关。
