铁与霉酚酸酯吸收之间不存在相互作用。
Absence of an interaction between iron and mycophenolate mofetil absorption.
作者信息
Ducray Patricia Sanwald, Banken Ludger, Gerber Marianne, Boutouyrie Bruno, Zandt Hagen
机构信息
Clinical Pharmacology Department, F. Hoffmann-La Roche Ltd, Basel, Switzerland.
出版信息
Br J Clin Pharmacol. 2006 Oct;62(4):492-5. doi: 10.1111/j.1365-2125.2005.02541.x.
AIM
To determine whether concomitant iron affects the absorption of mycophenolate mofetil.
METHODS
An open-label, single centre, randomized, crossover trial was conducted in 16 healthy males. Fasting subjects received mycophenolate mofetil alone (treatment A) or co-administered with iron (treatment B).
RESULTS
The mycophenolic acid AUC(0,24 h) for treatments A and B were 42.5 +/- 10.5 and 44.7 +/- 12.4 microg ml(-1) h, respectively. anova modelling showed the relative bioavailability of mycophenolate mofetil to be similar for the two treatments (90% confidence interval 0.92, 1.19).
CONCLUSIONS
There was no interaction between mycophenolate mofetil and iron supplements administered concomitantly to healthy fasting subjects.
目的
确定同时服用铁剂是否会影响霉酚酸酯的吸收。
方法
对16名健康男性进行了一项开放标签、单中心、随机交叉试验。空腹受试者单独服用霉酚酸酯（治疗A）或与铁剂联合服用（治疗B）。
结果
治疗A和治疗B的霉酚酸AUC(0,24 h)分别为42.5±10.5和44.7±12.4微克·毫升⁻¹·小时。方差分析模型显示，两种治疗中霉酚酸酯的相对生物利用度相似（90%置信区间0.92, 1.19）。
结论
对于健康的空腹受试者，霉酚酸酯与同时服用的铁补充剂之间没有相互作用。
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