Dan Z
Zhonghua Yi Xue Za Zhi. 1990 Jul;70(7):367-9, 26.
This experimental study was aimed at the effect of phentolamine used separately or in combination with pituitrin on hepatic and systemic hemodynamics in cirrhotic portal hypertensive dogs. The results showed that either of these drugs used separately could lead to reduction of portal venous pressure. Each of the drugs could also cause by-effect on systemic hemodynamics, or reduce hepatic blood flow. When phentolamine was used in combination with pituitrin no side effect was found in hepatic and systemic hemodynamics. It was suggested that phentolamine used in combination with pituitrin could efficiently decrease portal hypertension and counteract the side-effects. It would be useful in treatment of bleeding from esophageal variceal rupture in cirrhotic patients with portal hypertension.
本实验研究旨在探讨酚妥拉明单独使用或与垂体后叶素联合使用对肝硬化门静脉高压犬肝脏和全身血流动力学的影响。结果表明，这两种药物单独使用均可导致门静脉压力降低。每种药物也会对全身血流动力学产生副作用，或减少肝血流量。当酚妥拉明与垂体后叶素联合使用时，在肝脏和全身血流动力学方面未发现副作用。提示酚妥拉明与垂体后叶素联合使用可有效降低门静脉高压并抵消副作用。这对治疗门静脉高压肝硬化患者食管静脉曲张破裂出血将有帮助。
