Chen Z Y, Guo X P, Zhang X L, Cram W J, Li Z W
Chemistry Department, Huazhong University of Science and Technology, Wuhan 430074, China.
Comput Biol Med. 2007 Apr;37(4):559-62. doi: 10.1016/j.compbiomed.2006.08.006. Epub 2006 Sep 25.
A single ion channel signal was analysed by the power distribution fraction constructed by a discrete wavelet transform. Average opening time and energy distribution of the signal can be obtained directly by this method. The method can also be used when the signal is corrupted by noise. By contrast, the conventional frequency domain analysis method--power spectral density--is less effective. Power distribution fraction will therefore give more useful information in analysis of experimental ion channel signals, principally by giving values of the mean channel opening time. The method may be applied to distinguish different ion channels more efficiently and to find their reactions to drugs.
通过离散小波变换构建的功率分布分数对单个离子通道信号进行分析。利用该方法可直接获得信号的平均开放时间和能量分布。当信号被噪声干扰时，该方法同样适用。相比之下，传统的频域分析方法——功率谱密度——效果较差。因此，功率分布分数在分析实验离子通道信号时能提供更有用的信息，主要是通过给出平均通道开放时间的值。该方法可更有效地用于区分不同的离子通道，并找出它们对药物的反应。
