Carlson R W, Dorfman R F, Sikic B I
Department of Medicine, Stanford University, CA 94305.
Cancer. 1990 Nov 15;66(10):2092-4. doi: 10.1002/1097-0142(19901115)66:10<2092::aid-cncr2820661008>3.0.co;2-1.
Thymic carcinomas are rare malignant neoplasms of the thymic epithelium that are distinguished from the malignant thymomas by the presence of cytologic atypia. Thymic carcinomas may metastasize outside of the thorax and are associated with a very poor prognosis. Complete responses of thymic carcinoma to chemotherapy alone have not been reported. A 21-year-old man with metastatic undifferentiated carcinoma of probable thymic origin is presented who achieved a pathologic complete response with cisplatin, vinblastine, and bleomycin chemotherapy. Additional consolidative chemotherapy with cisplatin and etoposide was administered. The patient remains disease-free 5 years after diagnosis. Cisplatin, vinblastine, and bleomycin chemotherapy appears to have significant activity against thymic carcinoma.
胸腺癌是胸腺上皮的罕见恶性肿瘤，通过细胞异型性与恶性胸腺瘤相鉴别。胸腺癌可转移至胸部以外，预后极差。尚未有胸腺癌单纯化疗后完全缓解的报道。本文报告了一名21岁男性，患有可能起源于胸腺的转移性未分化癌，经顺铂、长春碱和博来霉素化疗后达到病理完全缓解。之后给予顺铂和依托泊苷进行巩固化疗。患者诊断后5年仍无疾病复发。顺铂、长春碱和博来霉素化疗似乎对胸腺癌有显著疗效。
