Horii Taiko, Suma Hisayoshi, Isomura Tadashi, Nomura Fumikazu, Hoshino Joji
Hayama Heart Center, Japan.
Ann Thorac Surg. 2006 Oct;82(4):1349-54; discussion 1354-5. doi: 10.1016/j.athoracsur.2006.04.077.
Mitral valve surgery is a recommended treatment for congestive heart failure; however, its effect for idiopathic dilated cardiomyopathy (DCM) with an extremely enlarged left ventricle (LV) is not well documented. We examined our long-term results of mitral valve surgery for idiopathic dilated cardiomyopathy.
Fifty-five patients of idiopathic dilated cardiomyopathy have undergone mitral valve surgery to treat intractable congestive heart failure since 1998. Forty-two patients were male with an average age of 55. Preoperative New York Heart Association functional class was III in 25, IV in 30, and 19 were dependent on inotropic infusion. The mitral valve was repaired in 37 patients and replaced in 18. The tricuspid valve was repaired in 35 patients and replaced in 3. We divided 46 elective cases into two groups by LV end-systolic volume index.
Postoperatively, an intraaortic balloon pump was required in 2 patients and a left ventricular assist device in 1; both were emergent cases. Hospital mortality was noted 4.3% in elective cases (2 of 46) and 14.5% in overall cases (8 of 55). One-year, 3-year, and 5-year survival rate of elective cases was 73.3%, 58.2%, and 51.7%, respectively. Left ventricle size has decreased and LV contractility has increased in a small LV group year by year, but those in a large LV volume group have not changed subsequently after surgery. There was a significant difference noted in the survival rate of the two groups divided by LV end-systolic volume index.
Mitral valve surgery for idiopathic dilated cardiomyopathy to treat end-stage heart failure is relatively safe and effective in elective status. However, isolated mitral reconstruction without any other type of surgery may not suffice for an extremely enlarged LV.
二尖瓣手术是治疗充血性心力衰竭的推荐疗法;然而,其对左心室(LV)极度扩大的特发性扩张型心肌病(DCM)的疗效尚无充分记录。我们研究了二尖瓣手术治疗特发性扩张型心肌病的长期结果。
自1998年以来,55例特发性扩张型心肌病患者接受了二尖瓣手术以治疗难治性充血性心力衰竭。42例为男性,平均年龄55岁。术前纽约心脏协会心功能分级为Ⅲ级的有25例,Ⅳ级的有30例,19例依赖于正性肌力药物输注。37例患者二尖瓣修复,18例置换。35例患者三尖瓣修复,3例置换。我们将46例择期手术病例按左心室收缩末期容积指数分为两组。
术后,2例患者需要主动脉内球囊反搏,1例需要左心室辅助装置;均为急诊病例。择期手术病例的医院死亡率为4.3%(46例中的2例),总体病例为14.5%(55例中的8例)。择期手术病例的1年、3年和5年生存率分别为73.3%、58.2%和51.7%。小左心室组的左心室大小逐年减小,左心室收缩力增加,但大左心室容积组术后未发生变化。按左心室收缩末期容积指数分组的两组生存率有显著差异。
二尖瓣手术治疗特发性扩张型心肌病的终末期心力衰竭在择期手术时相对安全有效。然而,单纯二尖瓣重建而不进行任何其他类型的手术可能不足以治疗极度扩大的左心室。