Medina-Tato David A, Watson Malcolm L, Ward Stephen G
Department of Pharmacy & Pharmacology, University of Bath, Claverton Down, Bath, BA2 7AY, UK.
Drug Discov Today. 2006 Oct;11(19-20):866-79. doi: 10.1016/j.drudis.2006.08.008. Epub 2006 Sep 7.
Respiratory diseases, including asthma and chronic obstructive pulmonary disease, are among the most significant diseases in terms of their disabling effects and healthcare burden. A characteristic feature of almost all respiratory diseases is the accumulation and activation of inflammatory leukocytes in the lung or airway. Recent advances in the understanding of the molecules and intracellular signalling events controlling these processes are now translating to new therapeutic entities. In this article, the process of leukocyte accumulation is summarized, together with the preclinical and clinical evidence supporting the utility of the individual components of this process as targets for disease therapy.
呼吸系统疾病，包括哮喘和慢性阻塞性肺疾病，就其致残影响和医疗负担而言，是最为严重的疾病之一。几乎所有呼吸系统疾病的一个特征是肺部或气道中炎症白细胞的聚集和活化。目前，在控制这些过程的分子和细胞内信号转导事件的理解方面取得的最新进展正在转化为新的治疗实体。在本文中，总结了白细胞聚集的过程，以及支持该过程各个组成部分作为疾病治疗靶点的临床前和临床证据。
