Murphy J, Beighton D, Clark D, Bartlett D
Departments of Prosthodontics and Microbiology, King's College London Dental Institute at Guy's, King's and St. Thomas' Hospitals, United Kingdom.
J Dent. 2007 Mar;35(3):214-7. doi: 10.1016/j.jdent.2006.08.003. Epub 2006 Sep 25.
Sodium hexametaphosphate (SHMP) is a widely used industrial preservative commonly found in children's drinks. In this paper we examined the effect of SHMP incorporated into children's drinks on acid production by the oral biofilm by monitoring salivary concentrations of lactic acid.
Twelve healthy adult subjects with an average age 36 years (range 26-54 years) consumed 10 ml from four children's beverages (Coca Cola and three types of Sunny Delight supplemented with SHMP) and a standard solution of sucrose. Saliva was collected at intervals following exposure of the oral biofilm to the drinks and the clearance of carbohydrates and the appearance of lactate was measured using standard enzymatic techniques.
All the carbohydrates derived from the drinks were cleared from saliva within 15 min of consumption. Comparison of two drinks [Sunny D Normal and Sunny C] with the same carbohydrate, but different SHMP concentrations suggested that SHMP in these beverages had no significant effect on acid production.
In this clinical study the role of SHMP, incorporated in common beverages, did not inhibit acid production from carbohydrates.
六偏磷酸钠（SHMP）是一种广泛使用的工业防腐剂，常见于儿童饮料中。在本文中，我们通过监测唾液中乳酸浓度，研究了添加到儿童饮料中的SHMP对口腔生物膜产酸的影响。
12名平均年龄36岁（范围26 - 54岁）的健康成年受试者饮用了四种儿童饮料（可口可乐和三种添加了SHMP的阳光喜乐饮料）以及蔗糖标准溶液各10毫升。在口腔生物膜接触饮料后，每隔一段时间收集唾液，并使用标准酶促技术测量碳水化合物的清除情况和乳酸的出现情况。
饮用后15分钟内，饮料中的所有碳水化合物都从唾液中清除。对两种碳水化合物相同但SHMP浓度不同的饮料[阳光喜乐普通款和阳光喜乐C款]进行比较，结果表明这些饮料中的SHMP对产酸没有显著影响。
在这项临床研究中，添加到普通饮料中的SHMP并未抑制碳水化合物产酸。
