Milic-Emili Joseph
Meakins-Christie Laboratories, McGill University, 3626 St. Urbain St., H2X 2P2, Montreal, Quebec, Canada.
COPD. 2004 Apr;1(1):85-92. doi: 10.1081/COPD-120028700.
In the present account it is proposed that in smokers the transition from peripheral airway disease to COPD is characterized by three sequential stages: Stage I, during which the closing volume eventually exceeds the functional residual capacity; Stage II, during which tidal expiratory flow limitation (EFL) is eventually exhibited; and Stage III, during which dynamic hyperinflation progressively increases leading to dyspnea and exercise limitation, which may be considered as markers of overt disease. Presence of airway closure (Stage I) and EFL (Stage II) in the tidal volume range may promote peripheral airway injury and accelerate the abnormalities of lung function. It is such injury that may determine which smoker is destined to develop COPD.
在本报告中，有人提出，在吸烟者中，从外周气道疾病到慢性阻塞性肺疾病（COPD）的转变具有三个连续阶段：第一阶段，在此期间闭合气量最终超过功能残气量；第二阶段，在此期间最终出现潮气呼气流量受限（EFL）；第三阶段，在此期间动态肺过度充气逐渐增加，导致呼吸困难和运动受限，这可被视为明显疾病的标志。潮气容积范围内气道闭合（第一阶段）和EFL（第二阶段）的存在可能会促进外周气道损伤，并加速肺功能异常。正是这种损伤可能决定哪些吸烟者注定会发展为COPD。
