Ulubay Gaye, Görek Asli, Savaş Serife, Oner Eyüboğlu Füsun
Department of Chest Disease, Faculty of Medicine, Başkent University, Ankara, Turkey.
Tuberk Toraks. 2005;53(4):340-6.
Hyperinflation is an important limiting factor for exercise performance in patients with chronic obstructive pulmonary disease (COPD). Hyperinflation can be determined by measuring residual volume (RV), functional residual capacity (FRC), and total lung capacity (TLC) at rest, and by measuring inspiratory capacity (IC) and end-expiratory lung volume (EELV) at maximal exercise. This study aimed to evaluate changes in hyperinflation parameters on maximal exercise in subjects with COPD. Patients with clinically stable COPD (n= 43) and healthy controls (n= 14) were included. Subjects performed pulmonary function tests and an incremental exercise test on cycle ergometry. Statistically significant differences (p< 0.05) were found regarding exercise test parameters including exercise duration, maximum oxygen uptake, breathing reserve, maximum minute ventilation, and breathing pattern between groups. There was significant increase in EELV (p< 0.05) and decrease in IC (p< 0.05) at maximum exercise when hyperinflation parameters were compared at baseline and maximum exercise. Our results showed that hyperinflation was evident at maximal exercise, although there were no hyperinflation findings at rest in subjects with COPD. We believe that in patients with COPD, it is better to evaluate hyperinflation at maximal exercise than at rest.
肺过度充气是慢性阻塞性肺疾病（COPD）患者运动能力的一个重要限制因素。肺过度充气可通过静息时测量残气量（RV）、功能残气量（FRC）和肺总量（TLC），以及在最大运动时测量吸气量（IC）和呼气末肺容积（EELV）来确定。本研究旨在评估COPD患者在最大运动时肺过度充气参数的变化。纳入了临床稳定的COPD患者（n = 43）和健康对照者（n = 14）。受试者进行了肺功能测试和递增运动试验（踏车测力计）。在包括运动持续时间、最大摄氧量、呼吸储备、最大分钟通气量和呼吸模式等运动试验参数方面，两组之间存在统计学显著差异（p < 0.05）。在基线和最大运动时比较肺过度充气参数时，最大运动时EELV显著增加（p < 0.05），IC显著降低（p < 0.05）。我们的结果表明，尽管COPD患者静息时无肺过度充气表现，但在最大运动时肺过度充气明显。我们认为，对于COPD患者，在最大运动时评估肺过度充气比在静息时更好。
