Ray Arundhati, Zoidl Georg, Wahle Petra, Dermietzel Rolf
Department of Neuroanatomy and Molecular Brain Research, Faculty of Medicine, Ruhr University, Bochum, Germany.
Cerebellum. 2006;5(3):189-92. doi: 10.1080/14734220500530082.
Pannexin1 and pannexin2 are members of the pannexin gene family which are widely expressed in the central nervous system. Here we present an overview of pannexin expression and distribution in the mouse cerebellum. Pannexin1 and pannexin2 are expressed in the Purkinje cells and in some cells of the granule cell layer. Pannexin2 is also expressed in the stellate cells of the molecular layer. A differential expression of pannexin1 and pannexin2 mRNA is observed during cerebellar development. These findings constitute the first indication of the involvement of pannexin molecules in the developing cerebellum. Although the functional relevance of these molecules remains currently unknown, the abundance of pannexins in the Purkinje cells suggests that they may contribute to the generation of cerebellar rhythms.
泛连接蛋白1和泛连接蛋白2是泛连接蛋白基因家族的成员，在中枢神经系统中广泛表达。在此，我们概述了泛连接蛋白在小鼠小脑中的表达和分布情况。泛连接蛋白1和泛连接蛋白2在浦肯野细胞和颗粒细胞层的一些细胞中表达。泛连接蛋白2也在分子层的星状细胞中表达。在小脑发育过程中观察到泛连接蛋白1和泛连接蛋白2 mRNA的差异表达。这些发现首次表明泛连接蛋白分子参与了小脑的发育。尽管这些分子的功能相关性目前尚不清楚，但浦肯野细胞中丰富的泛连接蛋白表明它们可能有助于产生小脑节律。
