• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
The lipid-associated 3D structure of SPA, a broad-spectrum neuropeptide antagonist with anticancer properties.具有抗癌特性的广谱神经肽拮抗剂SPA的脂质相关三维结构。
Biophys J. 2006 Dec 15;91(12):4478-89. doi: 10.1529/biophysj.106.089292. Epub 2006 Sep 22.
2
NMR and molecular modeling investigations of the neuropeptide substance P in the presence of 15 mM sodium dodecyl sulfate micelles.在15 mM十二烷基硫酸钠胶束存在下对神经肽P物质进行的核磁共振和分子建模研究。
Biopolymers. 1994 Nov;34(11):1449-62. doi: 10.1002/bip.360341102.
3
Membrane-induced secondary structures of neuropeptides: a comparison of the solution conformations adopted by agonists and antagonists of the mammalian tachykinin NK1 receptor.神经肽的膜诱导二级结构：哺乳动物速激肽NK1受体激动剂和拮抗剂所采用的溶液构象比较。
J Med Chem. 1998 Apr 23;41(9):1497-506. doi: 10.1021/jm970789x.
4
NMR conformational analyses on (des-bromo) neuropeptide B [1-23] and neuropeptide W [1-23]: the importance of alpha-helices, a cation-pi interaction and a beta-turn.对（去溴）神经肽B [1-23]和神经肽W [1-23]的核磁共振构象分析：α-螺旋、阳离子-π相互作用和β-转角的重要性
J Biomol Struct Dyn. 2005 Aug;23(1):77-90. doi: 10.1080/07391102.2005.10507049.
5
Molecular dynamics study of substance P peptides partitioned in a sodium dodecylsulfate micelle.在十二烷基硫酸钠胶束中分配的P物质肽的分子动力学研究。
Biophys J. 1999 Mar;76(3):1213-27. doi: 10.1016/S0006-3495(99)77285-1.
6
The conformation of substance P in lipid environments.P物质在脂质环境中的构象。
Biophys J. 1996 Apr;70(4):1716-27. doi: 10.1016/S0006-3495(96)79734-5.
7
Micelle bound structure and DNA interaction of brevinin-2-related peptide, an antimicrobial peptide derived from frog skin.源自蛙皮的抗菌肽brevinin-2相关肽的胶束结合结构及与DNA的相互作用
J Pept Sci. 2014 Oct;20(10):811-21. doi: 10.1002/psc.2673. Epub 2014 Jul 17.
8
Solution structures and model membrane interactions of Ctriporin, an anti-methicillin-resistant Staphylococcus aureus Peptide from Scorpion Venom.来自蝎毒的抗耐甲氧西林金黄色葡萄球菌肽Ctriporin的溶液结构及与模拟膜的相互作用
Biopolymers. 2014 Dec;101(12):1143-53. doi: 10.1002/bip.22519.
9
Structure of the bovine antimicrobial peptide indolicidin bound to dodecylphosphocholine and sodium dodecyl sulfate micelles.与十二烷基磷酸胆碱和十二烷基硫酸钠胶束结合的牛抗菌肽吲哚杀菌素的结构。
Biochemistry. 2000 Dec 26;39(51):15765-74.
10
Structure of the antimicrobial peptide tritrpticin bound to micelles: a distinct membrane-bound peptide fold.与胶束结合的抗菌肽tritrpticin的结构：一种独特的膜结合肽折叠。
Biochemistry. 1999 Dec 21;38(51):16749-55. doi: 10.1021/bi990701c.

引用本文的文献

1
-Prenylation of the indole ring improves the cytotoxicity of a short antagonist G analogue against small cell lung cancer.吲哚环的异戊二烯化提高了一种短拮抗剂G类似物对小细胞肺癌的细胞毒性。
Medchemcomm. 2017 Feb 17;8(3):551-558. doi: 10.1039/c6md00691d. eCollection 2017 Mar 1.
2
AM-37 and ST-36 Are Small Molecule Bombesin Receptor Antagonists.AM - 37和ST - 36是小分子蛙皮素受体拮抗剂。
Front Endocrinol (Lausanne). 2017 Jul 21;8:176. doi: 10.3389/fendo.2017.00176. eCollection 2017.
3
The micelle-associated 3D structures of Boc-Y(SO3)-Nle-G-W-Nle-D-2-phenylethylester (JMV-180) and CCK-8(s) share conformational elements of a calculated CCK1 receptor-bound model.Boc-Y(SO3)-Nle-G-W-Nle-D-2-苯乙酯（JMV-180）与胶束相关的三维结构和CCK-8(s)共享计算得出的CCK1受体结合模型的构象元件。
J Med Chem. 2008 Jul 10;51(13):3742-54. doi: 10.1021/jm701401j. Epub 2008 Jun 10.

本文引用的文献

1
Comparison of antagonist activity of spantide family at human neurokinin receptors measured by aequorin luminescence-based functional calcium assay.基于水母发光蛋白的功能性钙测定法测量的斯帕替德家族在人神经激肽受体上的拮抗剂活性比较。
Regul Pept. 2005 Nov;131(1-3):23-8. doi: 10.1016/j.regpep.2005.05.006.
2
Solution conformation of Substance P antagonists-[D-Arg1, D-Trp7,9, Leu11]-SP, [D-Arg1, D-Pro2, D-Trp7,9, Leu11]-SP and [D-Pro2, D-Trp7,9]-SP by CD, NMR and MD simulations.通过圆二色光谱（CD）、核磁共振（NMR）和分子动力学（MD）模拟研究P物质拮抗剂-[D-精氨酸1，D-色氨酸7,9，亮氨酸11]-P物质、[D-精氨酸1，D-脯氨酸2，D-色氨酸7,9，亮氨酸11]-P物质和[D-脯氨酸2，D-色氨酸7,9]-P物质的溶液构象
Peptides. 2005 May;26(5):875-85. doi: 10.1016/j.peptides.2004.12.001. Epub 2005 Jan 8.
3
Broad-spectrum G protein-coupled receptor antagonist, [D-Arg1,D-Trp5,7,9,Leu11]SP: a dual inhibitor of growth and angiogenesis in pancreatic cancer.广谱G蛋白偶联受体拮抗剂，[D-精氨酸1，D-色氨酸5,7,9，亮氨酸11]P物质：胰腺癌生长和血管生成的双重抑制剂
Cancer Res. 2005 Apr 1;65(7):2738-45. doi: 10.1158/0008-5472.CAN-04-3197.
4
Interfacial anchor properties of tryptophan residues in transmembrane peptides can dominate over hydrophobic matching effects in peptide-lipid interactions.跨膜肽中色氨酸残基的界面锚定特性在肽-脂质相互作用中可能比疏水匹配效应更具主导作用。
Biochemistry. 2003 May 13;42(18):5341-8. doi: 10.1021/bi027000r.
5
Intermolecular interactions between cholecystokinin-8 and the third extracellular loop of the cholecystokinin-2 receptor.胆囊收缩素-8与胆囊收缩素-2受体第三个细胞外环之间的分子间相互作用。
Biochemistry. 2002 Apr 9;41(14):4560-6. doi: 10.1021/bi0160009.
6
Neuropeptides as growth factors for normal and cancerous cells.
Trends Endocrinol Metab. 2002 Apr;13(3):128-34. doi: 10.1016/s1043-2760(01)00544-6.
7
Autocrine and paracrine signaling through neuropeptide receptors in human cancer.人类癌症中通过神经肽受体的自分泌和旁分泌信号传导。
Oncogene. 2001 Mar 26;20(13):1563-9. doi: 10.1038/sj.onc.1204183.
8
Conformation of a peptide ligand bound to its G-protein coupled receptor.与G蛋白偶联受体结合的肽配体的构象。
Nat Struct Biol. 2001 Feb;8(2):161-5. doi: 10.1038/84159.
9
How to measure and analyze tryptophan fluorescence in membranes properly, and why bother?如何正确测量和分析膜中的色氨酸荧光，以及为何要这么做？
Anal Biochem. 2000 Oct 15;285(2):235-45. doi: 10.1006/abio.2000.4773.
10
[Arg(6), D-Trp(7,9), N(me)Phe(8)]-substance P (6-11) (antagonist G) induces AP-1 transcription and sensitizes cells to chemotherapy.[精氨酸(6)、D-色氨酸(7,9)、N-甲基苯丙氨酸(8)]-P物质(6-11)(拮抗剂G)诱导AP-1转录并使细胞对化疗敏感。
Br J Cancer. 2000 Oct;83(7):941-8. doi: 10.1054/bjoc.2000.1362.

具有抗癌特性的广谱神经肽拮抗剂SPA的脂质相关三维结构。

The lipid-associated 3D structure of SPA, a broad-spectrum neuropeptide antagonist with anticancer properties.

作者信息

Keire David A, Kumar Mohanraja, Hu Weidong, Sinnett-Smith James, Rozengurt Enrique

机构信息

CURE Digestive Diseases Research Center, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA.

出版信息

Biophys J. 2006 Dec 15;91(12):4478-89. doi: 10.1529/biophysj.106.089292. Epub 2006 Sep 22.

DOI:10.1529/biophysj.106.089292
PMID:16997863
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1779918/
Abstract

[D-Arg(1), D-Trp(5,7,9), Leu(11)] substance P (SPA) belongs to a family of peptides including antagonist G and SpD that act as broad-spectrum neuropeptide antagonists at several peripheral receptors. The lipid-induced structure of these peptides may be important for the receptor interactions of these analogs. Thus we describe the tertiary structure of SPA in the presence of sodium dodecylsulfate micelles at pH 5.0, and 25 degrees C as determined from two-dimensional (1)H-NMR data recorded at 500 MHz. The resulting three-dimensional structure can be generally described as two type IV nonstandard turns around Arg(1), Pro(2), Lys(3), and Pro(4) and Gln(6), Trp(7), Phe(8), and Trp(9)* residues, respectively, inserted into the interfacial region of the micelles (the asterisks denote D-form amino acid). These turns juxtapose the N- and C-termini of SPA and may form the basis of this peptide's unique ability to inhibit peptide receptor interactions at multiple receptor types.

摘要

[D-精氨酸(1)，D-色氨酸(5,7,9)，亮氨酸(11)]P物质(SPA)属于一个肽家族，该家族包括拮抗剂G和SpD，它们在几种外周受体上作为广谱神经肽拮抗剂发挥作用。这些肽的脂质诱导结构可能对这些类似物与受体的相互作用很重要。因此，我们描述了在pH 5.0和25摄氏度下，在十二烷基硫酸钠胶束存在的情况下，SPA的三级结构，该结构由在500 MHz下记录的二维(1)H-NMR数据确定。所得的三维结构通常可描述为分别围绕精氨酸(1)、脯氨酸(2)、赖氨酸(3)和脯氨酸(4)以及谷氨酰胺(6)、色氨酸(7)、苯丙氨酸(8)和色氨酸(9)*残基的两个IV型非标准转角，插入到胶束的界面区域(星号表示D型氨基酸)。这些转角使SPA的N端和C端并列，可能构成该肽在多种受体类型上抑制肽受体相互作用的独特能力的基础。