Turner N C, Reis-Filho J S
The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Fulham Road, London, UK.
Oncogene. 2006 Sep 25;25(43):5846-53. doi: 10.1038/sj.onc.1209876.
Breast cancers arising in germline carriers of BRCA1 mutations have a characteristic phenotype that has been shown in many studies to differentiate BRCA1 tumours from sporadic tumours. Recently, it has become clear that the characteristic phenotype of BRCA1 tumours is due to expression of the basal-like phenotype. We review these phenotypes, the evidence for BRCA1 pathway dysfunction in sporadic basal-like cancers, and discuss the clinical significance of the basal-like phenotype for cancer genetics and treatment.
在携带BRCA1突变的种系携带者中发生的乳腺癌具有一种特征性表型，许多研究已表明这种表型可将BRCA1肿瘤与散发性肿瘤区分开来。最近，已经明确BRCA1肿瘤的特征性表型是由于基底样表型的表达所致。我们回顾这些表型、散发性基底样癌中BRCA1通路功能障碍的证据，并讨论基底样表型对癌症遗传学和治疗的临床意义。
