Steinberg Gregory R, Macaulay S Lance, Febbraio Mark A, Kemp Bruce E
St. Vincent's Institute, 41 Victoria Pd, Fitzroy, 3065 Victoria, Australia.
Can J Physiol Pharmacol. 2006 Jul;84(7):655-65. doi: 10.1139/y06-005.
AMP-activated protein kinase plays an important role in the regulation of lipid metabolism in response to metabolic stress and energy demand. It is also under endocrine control. AMPK acts at multiple steps and has a central role controlling fatty acid, triglyceride, and cholesterol synthesis, as well as the oxidation of fatty acids through direct phosphorylation effects and the control of gene transcription. As such, it can be considered to be the fat controller of the energy railroad. It is thought that AMPK may be a major mediator of the health benefits of exercise in mitigating the development of obesity and age-onset diseases.
AMP激活的蛋白激酶在响应代谢应激和能量需求时对脂质代谢的调节中起重要作用。它也受内分泌控制。AMPK在多个步骤发挥作用，在控制脂肪酸、甘油三酯和胆固醇合成以及通过直接磷酸化作用和基因转录控制来调节脂肪酸氧化方面起着核心作用。因此，它可被视为能量铁路的脂肪控制器。据认为，AMPK可能是运动对减轻肥胖和老年疾病发展有益健康作用的主要介质。
