孕期神经系统疾病的静脉注射免疫球蛋白治疗

Intravenous immunoglobulin therapy in neurological diseases during pregnancy.

作者信息

Ringel Isabel, Zettl Uwe K

出版信息

J Neurol. 2006 Sep;253 Suppl 5:V70-4. doi: 10.1007/s00415-006-5012-0.

Abstract

Immunological changes during pregnancy influence the course of neurological autoimmune diseases in different ways. In case of pregnancy immunomodulatory standard therapies such as interferon-beta, glatiramer acetate,monoclonal antibodies and cytostatics mostly should be discontinued. In those cases intravenous immunoglobulin (IVIg) therapy might be an alternative. In some diseases, contemporary publications describe positive therapeutic effects on the course of disease during or after pregnancy.

摘要

孕期的免疫变化以不同方式影响神经自身免疫性疾病的病程。在孕期，免疫调节标准疗法，如β干扰素、醋酸格拉替雷、单克隆抗体和细胞抑制剂大多应停用。在这些情况下，静脉注射免疫球蛋白（IVIg）疗法可能是一种替代方案。在某些疾病中，当代出版物描述了孕期或产后对疾病病程的积极治疗效果。