Myrup Charlotte, Hansen Charlotte C Thim, Andersen Else, Hellmuth Ellinor A
Hillerød Sygehus, Paediatrisk Afdeling.
Ugeskr Laeger. 2006 Sep 11;168(37):3129-31.
The objective of this study was to evaluate the implementation of the present Danish selective screening strategy for possible hepatitis B infection in pregnant women who themselves or whose partners originate from medium- or high-endemic hepatitis B areas of the world. We also investigated whether children of hepatitis B carriers were treated with immunoglobulin and vaccination.
We did a retrospective study of 1,924 birth notification forms of women who had delivered between 1 January and 30 June 2000 in Frederiksborg County, Denmark. Women were selected who had foreign-sounding names. The hospital case notes were examined to determine the women's countries of origin and their hepatitis B screening status. We then contacted the Department of Clinical Immunology of each hospital and the Danish State Serum Institute to double-check the women's screening status.
The study included 210 women, who made up nearly 11% of this cohort. Sixty-eight (32%) of the women had been tested according to the guidelines. One woman was a hepatitis B carrier. Her child had received immunoglobulin and vaccination within 24 hours of birth.
This study indicates that a selective antenatal screening program for hepatitis B is difficult to implement in daily clinical practice. The fact that only one third of this well-defined risk group had been tested for hepatitis B emphasizes the need for a universal antenatal screening program.
本研究的目的是评估丹麦现行的针对自身或其伴侣来自世界乙肝中高流行地区的孕妇进行乙肝感染可能性的选择性筛查策略的实施情况。我们还调查了乙肝携带者的子女是否接受了免疫球蛋白治疗和疫苗接种。
我们对丹麦腓特烈堡郡2000年1月1日至6月30日期间分娩的1924份妇女分娩通知表进行了回顾性研究。选择名字听起来像外国人的妇女。检查医院病历以确定这些妇女的原籍国及其乙肝筛查状况。然后我们联系了每家医院的临床免疫科和丹麦国家血清研究所，以再次核对这些妇女的筛查状况。
该研究纳入了210名妇女，占该队列的近11%。其中68名（32%）妇女按照指南进行了检测。有一名妇女是乙肝携带者。她的孩子在出生后24小时内接受了免疫球蛋白治疗和疫苗接种。
本研究表明，乙肝选择性产前筛查项目在日常临床实践中难以实施。这一明确界定的高危人群中只有三分之一接受了乙肝检测，这一事实凸显了实施普遍产前筛查项目的必要性。
