Feng Dennis, Fisher Michael, Liang Gui-Bai, Qian Xiaoxia, Brown Chris, Gurnett Anne, Leavitt Penny Sue, Liberator Paul A, Mathew John, Misura Andrew, Samaras Samantha, Tamas Tamas, Schmatz Dennis M, Wyvratt Matthew, Biftu Tesfaye
Merck Research Laboratories, Department of Medicinal Chemistry, Merck and Co., Inc., PO Box 2000, Rahway, NJ 07065, USA.
Bioorg Med Chem Lett. 2006 Dec 1;16(23):5978-81. doi: 10.1016/j.bmcl.2006.08.127. Epub 2006 Sep 26.
Compounds 10a-10d and 10i are very potent inhibitors of Eimeria tenella cGMP-dependent protein kinase (0.081-0.32 nM) and are very efficacious antiparasitic agents in vivo when administered to chickens at 12.5-25 ppm levels in the feed.
化合物10a - 10d和10i是柔嫩艾美耳球虫环磷酸鸟苷依赖性蛋白激酶的强效抑制剂（0.081 - 0.32纳摩尔），当以12.5 - 25 ppm的水平添加到鸡饲料中进行体内给药时，它们是非常有效的抗寄生虫剂。
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