有机催化对烯酮的对映选择性共轭加成反应。

Organocatalytic enantioselective conjugate additions to enones.

作者信息

Wang Jian, Li Hao, Zu Liansuo, Jiang Wei, Xie Hexin, Duan Wenhu, Wang Wei

机构信息

Department of Chemistry, University of New Mexico, Albuquerque, NM 87131-0001, USA.

出版信息

J Am Chem Soc. 2006 Oct 4;128(39):12652-3. doi: 10.1021/ja065187u.

DOI:10.1021/ja065187u

PMID:17002351

Abstract

Conjugate addition reactions of a wide range of nucleophilic enol species with enones, catalyzed by a cinchona alkaloid derived thiourea organocatalyst, have been developed with attending good yields and high enantioselectivities under a mild reaction condition. The general method provides an efficient approach to the preparation of versatile building blocks possessing various functional groups.

摘要

金鸡纳生物碱衍生的硫脲有机催化剂催化下，多种亲核烯醇物种与烯酮的共轭加成反应已被开发出来，在温和的反应条件下具有良好的产率和高对映选择性。该通用方法为制备具有各种官能团的多功能结构单元提供了一种有效途径。