Mastroyianni Sotiria D, Gionnis Dimitrios, Voudris Konstantinos, Skardoutsou Angeliki, Mizuguchi Masashi
Department of Neurology, University of Athens, Athens, Greece.
J Child Neurol. 2006 Oct;21(10):872-9. doi: 10.1177/08830738060210101401.
Acute necrotizing encephalopathy of childhood is a novel type of parainfectious encephalopathy with a racial and geographic predilection, rarely reported from other than East Asian areas. The objective was to describe the clinical, imaging, and other laboratory findings of non-Asian patients with acute necrotizing encephalopathy. Data were collected from three patients diagnosed in Athens over a 4-year period plus 16 cases reported from other European and North American countries. One of the Greek children died, and the other two had a normal outcome. A neuropathologic examination in the fatal case showed edematous necrosis without inflammatory, reactive, or proliferative changes. Data from Greek and other non-Asian patients support the homogeneity of the disease worldwide.
儿童急性坏死性脑病是一种新型的感染后脑病，具有种族和地域倾向性，除东亚地区外鲜有报道。目的是描述非亚洲急性坏死性脑病患者的临床、影像学及其他实验室检查结果。数据收集自雅典4年间诊断的3例患者以及其他欧洲和北美国家报告的16例病例。其中一名希腊儿童死亡，另外两名预后正常。对死亡病例进行的神经病理学检查显示为水肿性坏死，无炎症、反应性或增殖性改变。来自希腊和其他非亚洲患者的数据支持该病在全球范围内的同质性。
