Yamamoto Hitoshi, Kamiyama Noriko, Murakami Hiroshi, Miyamoto Yusaku, Fukuda Miho
Department of Pediatrics, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae, Kawasaki 216-8511, Japan.
Brain Dev. 2007 Apr;29(3):185-8. doi: 10.1016/j.braindev.2006.08.007. Epub 2006 Sep 26.
We report a three-year-old female with intractable epilepsy post West syndrome whose seizures disappeared following an acute viral infection, without changes in anti-epileptic therapy.
The female infant was born at term to a healthy mother after an uneventful pregnancy and delivery. At the age of five months, she developed intractable brief tonic spasms which had a series of infantile spasms, and an electroencephalogram indicated hypsarrhythmia. She was diagnosed with West syndrome. The seizures were uncontrollable with conventional therapy, including ACTH, vigabatrin, sodium valproate, clonazepam, zonisamide, and ketogenic diet. Daily multiple generalized tonic seizures and brief tonic spasms were observed before an episode of viral infection.
At the age of three years, the intractable seizures disappeared after a febrile rash illness due to human herpesvirus 7 (HHV-7) infection, without changes in anti-epileptic drugs.
The disappearance of intractable epileptic seizures following acute viral infections might be related to the inflammatory or immunologic processes associated with viral infections. This is the first documented case of spontaneous remission of intractable epileptic seizures following HHV-7 infection.
我们报告一名3岁患有韦斯特综合征后出现难治性癫痫的女性，其癫痫发作在一次急性病毒感染后消失，抗癫痫治疗未改变。
该女婴足月出生，母亲健康，孕期和分娩过程均正常。5个月大时，她出现难治性短暂强直痉挛，伴有一系列婴儿痉挛，脑电图显示高峰失律。她被诊断为韦斯特综合征。常规治疗包括促肾上腺皮质激素、氨己烯酸、丙戊酸钠、氯硝西泮、唑尼沙胺和生酮饮食，均无法控制癫痫发作。在一次病毒感染发作前，每天观察到多次全身性强直发作和短暂强直痉挛。
3岁时，在因人类疱疹病毒7（HHV - 7）感染导致的发热性皮疹疾病后，难治性癫痫发作消失，但抗癫痫药物未改变。
急性病毒感染后难治性癫痫发作的消失可能与病毒感染相关的炎症或免疫过程有关。这是首例记录在案的HHV - 7感染后难治性癫痫发作自发缓解的病例。
