Nazmi A, Huttly S R, Victora C G, Lima R C, Post P R, Elizalde J W L, Gerson B M C
Post-Graduate Program in Epidemiology, Federal University of Pelotas, Pelotas, RS, Brazil.
Eur J Clin Nutr. 2007 Mar;61(3):434-7. doi: 10.1038/sj.ejcn.1602535. Epub 2006 Sep 27.
The fetal origins hypothesis states that nutritional deprivation in utero affects fetal development and contributes to the incidence of diseases associated with the metabolic syndrome in later life. This study investigated whether haemoglobin (Hb) A(1c), an indicator of blood glucose, varied among healthy male adolescents according to their fetal growth rate, in a middle-income setting. Participants were men aged 18 years, belonging to the 1982 Pelotas birth cohort. Complete data, including gestational age and Hb A(1c) at age 18 years, were available for 197 individuals. There was an inverse association between mean Hb A(1c) and birthweight for the gestational age, but not birthweight alone. The association remained significant after adjustment for family income and mother's education, as well as for body mass index at 18 years (P for trend=0.01 and 0.03, respectively).
胎儿起源假说指出，子宫内的营养剥夺会影响胎儿发育，并导致日后与代谢综合征相关疾病的发生率增加。本研究在一个中等收入环境中，调查了作为血糖指标的糖化血红蛋白（Hb）A1c在健康男性青少年中是否根据其胎儿生长速度而有所不同。参与者为1982年佩洛塔斯出生队列中18岁的男性。197名个体可获得完整数据，包括胎龄和18岁时的Hb A1c。对于胎龄而言，平均Hb A1c与出生体重之间存在负相关，但单独与出生体重无关。在调整家庭收入、母亲教育程度以及18岁时的体重指数后，这种关联仍然显著（趋势P值分别为0.01和0.03）。
